rokitamycin and Abnormalities--Drug-Induced

rokitamycin has been researched along with Abnormalities--Drug-Induced* in 1 studies

Other Studies

1 other study(ies) available for rokitamycin and Abnormalities--Drug-Induced

Article	Year
[Reproduction study of rokitamycin. Teratological study in rabbits]. The Japanese journal of antibiotics, 1987, Volume: 40, Issue:3 A teratological study was performed on rokitamycin (TMS-19-Q), a new macrolide antibiotic, using rabbits. TMS-19-Q, at dose levels of 100, 300 and 600 mg/kg, was orally administered from the day 6 to the day 18 of gestation to dams. Diarrhea and decrease in body weight gain and food consumption were observed in dams at or above 300 mg/kg. Decrease in numbers of live fetuses was observed at dose levels of 300 and 600 mg/kg but there was no teratogenicity at any dose levels. The maximum non-toxic dose level for TMS-19-Q in this study was 100 mg/kg. Topics: Abnormalities, Drug-Induced; Animals; Drug Evaluation, Preclinical; Female; Fetus; Leucomycins; Male; Miocamycin; Pregnancy; Rabbits; Reproduction	1987

Article

Year

[Reproduction study of rokitamycin. Teratological study in rabbits].

The Japanese journal of antibiotics, 1987, Volume: 40, Issue:3

A teratological study was performed on rokitamycin (TMS-19-Q), a new macrolide antibiotic, using rabbits. TMS-19-Q, at dose levels of 100, 300 and 600 mg/kg, was orally administered from the day 6 to the day 18 of gestation to dams. Diarrhea and decrease in body weight gain and food consumption were observed in dams at or above 300 mg/kg. Decrease in numbers of live fetuses was observed at dose levels of 300 and 600 mg/kg but there was no teratogenicity at any dose levels. The maximum non-toxic dose level for TMS-19-Q in this study was 100 mg/kg.

Topics: Abnormalities, Drug-Induced; Animals; Drug Evaluation, Preclinical; Female; Fetus; Leucomycins; Male; Miocamycin; Pregnancy; Rabbits; Reproduction

1987