roflumilast has been researched along with Dry-Eye-Syndromes* in 1 studies
1 other study(ies) available for roflumilast and Dry-Eye-Syndromes
| Article | Year |
|---|---|
Water-soluble PDE4 inhibitors for the treatment of dry eye.
PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats. Topics: 4-Aminopyridine; Animals; Anti-Inflammatory Agents; Binding Sites; Computer Simulation; Coumarins; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dry Eye Syndromes; Phosphodiesterase 4 Inhibitors; Rabbits; Rats; Water | 2010 |