rofecoxib has been researched along with Seizures in 8 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizures were induced in Sprague-Dawley rats with kainic acid (10 mg/kg, i." | 5.33 | Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat. ( Hillered, L; Kunz, T; Marklund, N; Oliw, EH, 2005) |
| " Despite this increase, chronic rofecoxib treatment did not attenuate the severity of acute PTZ-induced seizures and failed to alter kindling development or maintenance." | 3.77 | Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition. ( Claycomb, RJ; Hewett, JA; Hewett, SJ, 2011) |
| "Acute epileptic seizure activity was modeled using two mechanistically distinct chemoconvulsants, kainic acid (KA) and pentylenetetrazole (PTZ)." | 1.38 | Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2. ( Claycomb, RJ; Hewett, JA; Hewett, SJ, 2012) |
| "Pretreatment with rofecoxib (1." | 1.35 | Rofecoxib potentiates the anticonvulsant effect of topiramate. ( Akula, KK; Dhir, A; Kulkarni, SK, 2008) |
| "Seizures were induced in Sprague-Dawley rats with kainic acid (10 mg/kg, i." | 1.33 | Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat. ( Hillered, L; Kunz, T; Marklund, N; Oliw, EH, 2005) |
| "Pretreatment with rofecoxib (1-5." | 1.33 | Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice. ( Dhir, A; Kulkarni, SK, 2006) |
| "Treatment with rofecoxib selectively and significantly (P < 0." | 1.31 | The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus. ( Kunz, T; Oliw, EH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akula, KK | 3 |
| Dhir, A | 4 |
| Kulkarni, SK | 4 |
| Claycomb, RJ | 2 |
| Hewett, SJ | 2 |
| Hewett, JA | 2 |
| Kunz, T | 2 |
| Marklund, N | 1 |
| Hillered, L | 1 |
| Oliw, EH | 2 |
8 other studies available for rofecoxib and Seizures
| Article | Year |
|---|---|
Effect of various antiepileptic drugs in a pentylenetetrazol-induced seizure model in mice.
Topics: Adenosine; Algorithms; Animals; Anti-Inflammatory Agents; Anticonvulsants; Barbiturates; Carbamazepi | 2009 |
Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cell Death; Convulsants; Cyclooxygenase 2; Cyclooxygenas | 2011 |
Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Interleukin-1beta; Kainic Acid; Lactones; Mice | 2012 |
Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat.
Topics: Animals; Cell Death; Cyclooxygenase 2 Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; In Si | 2005 |
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2 Inhibitors; Drug Synergism; Drug Therapy, Combination; La | 2006 |
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism.
Topics: Adenine; Adenosine; Analysis of Variance; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Anim | 2008 |
Rofecoxib potentiates the anticonvulsant effect of topiramate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2008 |
The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epile | 2001 |