rofecoxib has been researched along with Peptic Ulcer Perforation in 3 studies
Peptic Ulcer Perforation: Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We analysed pooled data from two identical double-blind, randomized, 12-week endoscopy studies which compared the gastroduodenal toxicity of placebo (n=371), rofecoxib 25 mg (n=390), rofecoxib 50 mg (n=379), and ibuprofen 2400 mg daily (n=376) in patients with osteoarthritis." | 5.09 | Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials. ( Bolognese, JA; Harper, SE; Hawkey, CJ; Laine, L; Mortensen, E; Quan, HU, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lanas, A | 1 |
| Baron, JA | 1 |
| Sandler, RS | 1 |
| Horgan, K | 1 |
| Bolognese, J | 1 |
| Oxenius, B | 1 |
| Quan, H | 1 |
| Watson, D | 1 |
| Cook, TJ | 1 |
| Schoen, R | 1 |
| Burke, C | 1 |
| Loftus, S | 1 |
| Niv, Y | 1 |
| Ridell, R | 1 |
| Morton, D | 1 |
| Bresalier, R | 1 |
| Laudanno, OM | 1 |
| Cesolari, JA | 1 |
| Esnarriaga, J | 1 |
| Rista, L | 1 |
| Piombo, G | 1 |
| Maglione, C | 1 |
| Aramberry, LJ | 1 |
| Sambrano, JS | 1 |
| Godoy, A | 1 |
| Rocaspana, A | 1 |
| Hawkey, CJ | 1 |
| Laine, L | 1 |
| Harper, SE | 1 |
| Quan, HU | 1 |
| Bolognese, JA | 1 |
| Mortensen, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomized, Parallel-Group, Placebo-Controlled, Double-Blind Study With In-House Blinding to Determine the Effect of 156 Weeks of Treatment With MK0966 on the Recurrence of Neoplastic Polyps of the Large Bowel in Patients With a History of [NCT00282386] | Phase 3 | 2,586 participants (Actual) | Interventional | 1999-12-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for rofecoxib and Peptic Ulcer Perforation
| Article | Year |
|---|---|
Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial.
Topics: Adenomatous Polyps; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Europe; | 2007 |
Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials.
Topics: Aged; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; | 2001 |
1 other study available for rofecoxib and Peptic Ulcer Perforation
| Article | Year |
|---|---|
[Gastrointestinal damage induced by celecoxib and rofecoxib in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Disease Mode | 2000 |