rofecoxib and Hemorrhage, Peptic Ulcer studies

rofecoxib and Hemorrhage, Peptic Ulcer

Research Excerpts

Excerpt	Relevance	Reference
"We analysed pooled data from two identical double-blind, randomized, 12-week endoscopy studies which compared the gastroduodenal toxicity of placebo (n=371), rofecoxib 25 mg (n=390), rofecoxib 50 mg (n=379), and ibuprofen 2400 mg daily (n=376) in patients with osteoarthritis."	5.09	Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials. ( Bolognese, JA; Harper, SE; Hawkey, CJ; Laine, L; Mortensen, E; Quan, HU, 2001)

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

6 (100.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Lima Rodríguez, EM	1
Calvo Romero, JM	1
Lanas, A	1
Baron, JA	1
Sandler, RS	1
Horgan, K	1
Bolognese, J	1
Oxenius, B	1
Quan, H	1
Watson, D	1
Cook, TJ	1
Schoen, R	1
Burke, C	1
Loftus, S	1
Niv, Y	1
Ridell, R	1
Morton, D	1
Bresalier, R	1
Hawkey, CJ	1
Laine, L	1
Harper, SE	1
Quan, HU	1
Bolognese, JA	1
Mortensen, E	1

Studies

Lima Rodríguez, EM

Calvo Romero, JM

Lanas, A

Baron, JA

Sandler, RS

Horgan, K

Bolognese, J

Oxenius, B

Quan, H

Watson, D

Cook, TJ

Schoen, R

Burke, C

Loftus, S

Niv, Y

Ridell, R

Morton, D

Bresalier, R

Hawkey, CJ

Laine, L

Harper, SE

Quan, HU

Bolognese, JA

Mortensen, E

Clinical Trials (1)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Multicenter, Randomized, Parallel-Group, Placebo-Controlled, Double-Blind Study With In-House Blinding to Determine the Effect of 156 Weeks of Treatment With MK0966 on the Recurrence of Neoplastic Polyps of the Large Bowel in Patients With a History of [NCT00282386]	Phase 3	2,586 participants (Actual)	Interventional	1999-12-23	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

A Multicenter, Randomized, Parallel-Group, Placebo-Controlled, Double-Blind Study With In-House Blinding to Determine the Effect of 156 Weeks of Treatment With MK0966 on the Recurrence of Neoplastic Polyps of the Large Bowel in Patients With a History of [NCT00282386]

Phase 3

2,586 participants (Actual)

Interventional

1999-12-23

Completed

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for rofecoxib and Hemorrhage, Peptic Ulcer

Article	Year
Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial. Gastroenterology, 2007, Volume: 132, Issue:2 Topics: Adenomatous Polyps; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Europe;	2007
Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials. Alimentary pharmacology & therapeutics, 2001, Volume: 15, Issue:10 Topics: Aged; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method;	2001

Article

Year

Peptic ulcer and bleeding events associated with rofecoxib in a 3-year colorectal adenoma chemoprevention trial.

Gastroenterology, 2007, Volume: 132, Issue:2

Topics: Adenomatous Polyps; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Europe;

2007

Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials.

Alimentary pharmacology & therapeutics, 2001, Volume: 15, Issue:10

Topics: Aged; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method;

2001

Other Studies

4 other studies available for rofecoxib and Hemorrhage, Peptic Ulcer

Article	Year
[Coxib instead of NSAID plus gastric acid inhibitor. Protection for the small intestine]. MMW Fortschritte der Medizin, 2004, Mar-25, Volume: 146, Issue:13 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Clinical Trials a	2004
[Gastro-intestinal toxicity of rofecoxib]. Atencion primaria, 2005, Feb-15, Volume: 35, Issue:2 Topics: Aged; Cyclooxygenase Inhibitors; Drug-Related Side Effects and Adverse Reactions; Duodenal Ulcer; Fe	2005
[Stomach-saving "Coxibs". No reason for therapeutic risks]. MMW Fortschritte der Medizin, 2001, Jan-18, Volume: 143, Issue:3 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Humans; Lactones; Peptic Ulc	2001
[Elderly patient with rheumatoid arthritis. Minimizing the peptic ulcer hemorrhage risk]. MMW Fortschritte der Medizin, 2001, Aug-09, Volume: 143, Issue:31-32 Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cycl	2001

Article

Year

[Coxib instead of NSAID plus gastric acid inhibitor. Protection for the small intestine].

MMW Fortschritte der Medizin, 2004, Mar-25, Volume: 146, Issue:13

Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Clinical Trials a

2004

[Gastro-intestinal toxicity of rofecoxib].

Atencion primaria, 2005, Feb-15, Volume: 35, Issue:2

Topics: Aged; Cyclooxygenase Inhibitors; Drug-Related Side Effects and Adverse Reactions; Duodenal Ulcer; Fe

2005

[Stomach-saving "Coxibs". No reason for therapeutic risks].

MMW Fortschritte der Medizin, 2001, Jan-18, Volume: 143, Issue:3

Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Humans; Lactones; Peptic Ulc

2001

[Elderly patient with rheumatoid arthritis. Minimizing the peptic ulcer hemorrhage risk].

MMW Fortschritte der Medizin, 2001, Aug-09, Volume: 143, Issue:31-32

Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Cycl

2001