Page last updated: 2024-11-04

rofecoxib and Edema

rofecoxib has been researched along with Edema in 41 studies

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
" This safety study compared the GI tolerability, the blood pressure (BP) profile and the incidence of oedema with lumiracoxib and rofecoxib in the treatment of OA."9.13A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients. ( Krammer, G; Stricker, K; Yu, S, 2008)
" This study evaluated the effects of celecoxib 200 mg/day and rofecoxib 25 mg/day on blood pressure (BP) and edema in a 6-week, randomized, parallel-group, double-blind study in patients > or =65 years of age with osteoarthritis who were treated with fixed antihypertensive regimens."9.10Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis. ( Bello, AE; Fort, JG; Puma, JA; Whelton, A; White, WB, 2002)
" Recently, head-to-head, randomized, controlled trials have shown a significantly higher incidence of blood pressure (BP) destabilization and clinically significant edema with rofecoxib than with celecoxib among older, hypertensive patients with osteoarthritis (OA)."7.72A model analysis of costs of blood pressure destabilization and edema associated with rofecoxib and celecoxib among older patients with osteoarthritis and hypertension in a Medicare Choice population. ( Becker, RV; Burke, TA; McCoy, MA; Trotter, JP, 2003)
"To investigate the relationship between nonselective nonsteroidal antiinflammatory drugs (NS NSAID), rofecoxib, celecoxib, and risk of edema and blood pressure destabilization in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) receiving ordinary clinic care."7.72Blood pressure destabilization and edema among 8538 users of celecoxib, rofecoxib, and nonselective nonsteroidal antiinflammatory drugs (NSAID) and nonusers of NSAID receiving ordinary clinical care. ( Pettitt, D; Wolfe, F; Zhao, S, 2004)
"This study evaluates the action of celecoxib and rofecoxib, two selective cyclooxygenase-2 (COX-2) inhibitors in two acute models of inflammation, carrageenan (Cg)-induced rat pleurisy, and paw oedema formation."7.71Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. ( Calixto, JB; Pinheiro, RM, 2002)
" Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability."7.71A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002)
" This safety study compared the GI tolerability, the blood pressure (BP) profile and the incidence of oedema with lumiracoxib and rofecoxib in the treatment of OA."5.13A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients. ( Krammer, G; Stricker, K; Yu, S, 2008)
"A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy (capecitabine or temozolomide) in patients with high-grade gliomas (glioblastoma or anaplastic glioma)."5.12Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. ( Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E, 2007)
" This study evaluated the effects of celecoxib 200 mg/day and rofecoxib 25 mg/day on blood pressure (BP) and edema in a 6-week, randomized, parallel-group, double-blind study in patients > or =65 years of age with osteoarthritis who were treated with fixed antihypertensive regimens."5.10Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis. ( Bello, AE; Fort, JG; Puma, JA; Whelton, A; White, WB, 2002)
" The compounds were evaluated for their anti-inflammatory activity in carrageenan induced rat paw edema model taking rofecoxib and indomethacin as standard drugs."3.85Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect. ( Bali, A; Chaudhari, BB; Sharma, R, 2017)
"A series of 3-alkoxy-4-methanesulfonamido acetophenone derivatives were synthesized and evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model."3.78Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents. ( Bali, A; Deb, PK; Ohri, R, 2012)
"Substituted thiazoles with different structural features were synthesized and screened for their anti-inflammatory activity in acute carrageenin induced rat paw edema model and chronic formalin induced rat paw edema model."3.742-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. ( Franklin, PX; Nivsarkar, M; Padh, H; Pillai, AD; Rathod, PD; Sudarsanam, V; Vasu, KK; Yerande, S, 2008)
"0032 muM) and COX-2 selectivity (SI > 120 000), 14s exhibited moderate antiinflammatory activity compared to celecoxib in a carrageenan-induced rat paw edema assay."3.72Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. ( Amini, M; Habeeb, AG; Knaus, EE; Li, H; Praveen Rao, PN, 2003)
" Recently, head-to-head, randomized, controlled trials have shown a significantly higher incidence of blood pressure (BP) destabilization and clinically significant edema with rofecoxib than with celecoxib among older, hypertensive patients with osteoarthritis (OA)."3.72A model analysis of costs of blood pressure destabilization and edema associated with rofecoxib and celecoxib among older patients with osteoarthritis and hypertension in a Medicare Choice population. ( Becker, RV; Burke, TA; McCoy, MA; Trotter, JP, 2003)
"The anti-inflammatory activity of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), was studied on the carrageenan-induced paw inflammation in the rat."3.72Studies on the anti-inflammatory effect of fluoxetine in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR, 2004)
"To investigate the relationship between nonselective nonsteroidal antiinflammatory drugs (NS NSAID), rofecoxib, celecoxib, and risk of edema and blood pressure destabilization in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) receiving ordinary clinic care."3.72Blood pressure destabilization and edema among 8538 users of celecoxib, rofecoxib, and nonselective nonsteroidal antiinflammatory drugs (NSAID) and nonusers of NSAID receiving ordinary clinical care. ( Pettitt, D; Wolfe, F; Zhao, S, 2004)
"The aim of this study was to describe physician-reported management of clinically significant edema and/or destabilized blood pressure in patients with osteoarthritis (OA) and hypertension when initiating therapy with rofecoxib or celecoxib."3.71Physician-reported management of edema and destabilized blood pressure in cyclooxygenase-2-specific inhibitor users with osteoarthritis and treated hypertension. ( Bristol, S; Burke, TA; May, C; Osterhaus, JT; Wentworth, C; Whelton, A, 2002)
"This study evaluates the action of celecoxib and rofecoxib, two selective cyclooxygenase-2 (COX-2) inhibitors in two acute models of inflammation, carrageenan (Cg)-induced rat pleurisy, and paw oedema formation."3.71Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. ( Calixto, JB; Pinheiro, RM, 2002)
" Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability."3.71A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002)
"Treatment with indomethacin (2 mg/kg), rofecoxib, (10 mg/kg), or dexamethasone (2 mg/kg) significantly reduced the BaV- and BjV-induced oedema formation."1.34Role of cyclooxygenases in oedema-forming activity of bothropic venoms. ( Gutierrez, JM; Olivo, Rdo A; Teixeira, CF; Wallace, JL; Zamuner, SR, 2007)
"Rofecoxib is a poorly water soluble nonsteroidal anti-inflammatory drug with a poor dissolution profile."1.33Characteristics of rofecoxib-polyethylene glycol 4000 solid dispersions and tablets based on solid dispersions. ( Desai, KG; Liu, C, 2005)
"To determine the prevalence of chronic use of rofecoxib 50 mg."1.32High frequency of use of rofecoxib at greater than recommended doses: cause for concern. ( Arbogast, PG; Daugherty, JR; Graham, DJ; Griffin, MR; Ray, WA; Stein, CM, 2004)
"Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw."1.31Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM, 2002)
"2."1.31Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation. ( Bakhle, YS; Chaves, CT; Ferreira-Alves, DL; Francischi, JN; Lima, AS; Moura, AC; Rocha, OA, 2002)
" Both exhibit good oral bioavailability and are potent in standard models of pain, fever, and inflammation yet have a much reduced effect on the GI integrity of rats compared to standard nonsteroidal antiflammatory drugs."1.302,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors. ( Black, WC; Brideau, C; Chan, CC; Charleson, S; Chauret, N; Claveau, D; Ethier, D; Gordon, R; Greig, G; Guay, J; Hughes, G; Jolicoeur, P; Leblanc, Y; Nicoll-Griffith, D; Ouimet, N; Prasit, P; Riendeau, D; Visco, D; Wang, Z; Xu, L, 1999)
"Rofecoxib is a potent inhibitor of the COX-2-dependent production of PGE(2) in human osteosarcoma cells (IC(50) = 26 +/- 10 nM) and Chinese hamster ovary cells expressing human COX-2 (IC(50) = 18 +/- 7 nM) with a 1000-fold selectivity for the inhibition of COX-2 compared with the inhibition of COX-1 activity (IC(50) > 50 microM in U937 cells and IC(50) > 15 microM in Chinese hamster ovary cells expressing human COX-1)."1.30Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. ( Boyce, S; Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Ethier, D; Evans, J; Ford-Hutchinson, AW; Forrest, MJ; Gauthier, JY; Gordon, R; Gresser, M; Guay, J; Kargman, S; Kennedy, B; Leblanc, Y; Leger, S; Mancini, J; O'Neill, GP; Ouellet, M; Patrick, D; Percival, MD; Perrier, H; Prasit, P; Rodger, I, 1999)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (7.32)18.2507
2000's33 (80.49)29.6817
2010's5 (12.20)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Black, WC2
Brideau, C3
Chan, CC3
Charleson, S3
Chauret, N1
Claveau, D1
Ethier, D2
Gordon, R3
Greig, G1
Guay, J2
Hughes, G2
Jolicoeur, P1
Leblanc, Y2
Nicoll-Griffith, D1
Ouimet, N1
Riendeau, D2
Visco, D1
Wang, Z2
Xu, L1
Prasit, P3
Shin, SS2
Noh, MS2
Byun, YJ1
Choi, JK2
Kim, JY2
Lim, KM2
Ha, JY1
Kim, JK2
Lee, CH1
Chung, S2
Cromlish, W2
Grimm, EL1
Leger, S2
Li, CS1
Thérien, M1
Xu, LJ1
Pal, M1
Madan, M1
Padakanti, S1
Pattabiraman, VR1
Kalleda, S1
Vanguri, A1
Mullangi, R1
Mamidi, NV1
Casturi, SR1
Malde, A1
Gopalakrishnan, B1
Yeleswarapu, KR1
Praveen Rao, PN1
Amini, M1
Li, H1
Habeeb, AG1
Knaus, EE3
Byun, Y1
Lee, KW1
Moh, JH1
Jeong, YS1
Choi, YH1
Koh, HJ1
Park, YH1
Oh, YI1
Rao, PN2
Uddin, MJ1
Chen, QH1
Franklin, PX1
Pillai, AD1
Rathod, PD1
Yerande, S1
Nivsarkar, M1
Padh, H1
Vasu, KK1
Sudarsanam, V1
Anzini, M1
Rovini, M1
Cappelli, A1
Vomero, S1
Manetti, F1
Botta, M1
Sautebin, L1
Rossi, A1
Pergola, C1
Ghelardini, C1
Norcini, M1
Giordani, A1
Makovec, F1
Anzellotti, P1
Patrignani, P1
Biava, M1
Tan, CM1
Chen, GS1
Chen, CS1
Chang, PT1
Chern, JW1
Bali, A2
Ohri, R1
Deb, PK1
Sharma, R1
Chaudhari, BB1
Kumar, R1
Saha, N1
Purohit, P1
Garg, SK1
Seth, K1
Meena, VS1
Dubey, S1
Dave, K1
Goyal, R1
Sharma, SS1
Banerjee, UC1
Chakraborti, AK1
Stricker, K1
Yu, S1
Krammer, G1
Finn, A1
Oerther, SC1
Osterhaus, JT1
Burke, TA2
May, C1
Wentworth, C1
Whelton, A2
Bristol, S1
El-Shenawy, SM1
Abdel-Salam, OM2
Baiuomy, AR2
El-Batran, S1
Arbid, MS2
White, WB1
Bello, AE1
Puma, JA1
Fort, JG1
Francischi, JN1
Chaves, CT1
Moura, AC1
Lima, AS1
Rocha, OA1
Ferreira-Alves, DL1
Bakhle, YS1
Pinheiro, RM1
Calixto, JB1
Weaver, A1
Alderman, M1
Sperling, R1
Becker, RV1
McCoy, MA1
Trotter, JP1
Barbosa, AM1
do Amaral, RO1
Teixeira, CF2
Hyslop, S1
Cogo, JC1
Baboota, S1
Dhaliwal, M1
Kohli, K1
Ali, J1
Griffin, MR1
Stein, CM1
Graham, DJ1
Daugherty, JR1
Arbogast, PG1
Ray, WA1
Wolfe, F1
Zhao, S1
Pettitt, D1
Vajja, BN1
Juluri, S1
Kumari, M1
Kole, L1
Chakrabarti, R1
Joshi, VD1
Warzecha, Z1
Dembinski, A1
Ceranowicz, P1
Konturek, SJ1
Dembinski, M1
Pawlik, WW1
Tomaszewska, R1
Stachura, J1
Kusnierz-Cabala, B1
Naskalski, JW1
Konturek, PC1
Liu, C1
Desai, KG1
Okumura, T2
Murata, Y2
Hizue, M1
Matsuura, T1
Naganeo, R1
Kanai, Y1
Murase, A2
Sakakibara, A1
Fujita, I1
Nakao, K1
Guindon, J1
LoVerme, J1
De Léan, A1
Piomelli, D1
Beaulieu, P1
Valat, JP1
Deray, G1
Héloire, F1
Olivo, Rdo A1
Wallace, JL1
Gutierrez, JM1
Zamuner, SR1
Feng, Y1
Ju, H1
Yang, B1
An, H1
Hau, P1
Kunz-Schughart, L1
Bogdahn, U1
Baumgart, U1
Hirschmann, B1
Weimann, E1
Muhleisen, H1
Ruemmele, P1
Steinbrecher, A1
Reichle, A1
Taniguchi, K1
Nii, A1
Boyce, S1
Evans, J1
Ford-Hutchinson, AW1
Forrest, MJ1
Gauthier, JY1
Gresser, M1
Kargman, S1
Kennedy, B1
Mancini, J1
O'Neill, GP1
Ouellet, M1
Patrick, D1
Percival, MD1
Perrier, H1
Rodger, I1
Gertz, BJ1
Krupa, D1
Bolognese, JA1
Sperling, RS1
Reicin, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A 6-Week Multicenter, Randomized, Double-Blind, Double-Dummy, Active-Controlled Parallel Group Clinical Saftey Study to Evaluate Incidence of Predefined Gastrointestinal Adverse Events and Peripheral Edema in Subjects With Primary Osteoarthritis Treated W[NCT00637949]Phase 3309 participants (Actual)Interventional2000-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for rofecoxib and Edema

ArticleYear
[Are there any differences in the cardiovascular tolerance between classical NSAIDs and coxibs?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseas

2006

Trials

4 trials available for rofecoxib and Edema

ArticleYear
A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients.
    BMC musculoskeletal disorders, 2008, Sep-08, Volume: 9

    Topics: Aged; Arthralgia; Blood Pressure; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationshi

2008
Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis.
    The American journal of cardiology, 2002, Nov-01, Volume: 90, Issue:9

    Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure;

2002
Effects of a selective cyclooxygenase-2 inhibitor on postoperative inflammatory reaction and pain after total knee replacement.
    The journal of pain, 2008, Volume: 9, Issue:1

    Topics: Administration, Oral; Aged; Analgesics, Opioid; Arthritis; Arthroplasty, Replacement, Knee; Chemotax

2008
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
    Oncology, 2007, Volume: 73, Issue:1-2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabin

2007

Other Studies

36 other studies available for rofecoxib and Edema

ArticleYear
2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.
    Journal of medicinal chemistry, 1999, Apr-08, Volume: 42, Issue:7

    Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Biological Availability; Carrageenan; Ce

1999
2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2001, Jan-22, Volume: 11, Issue:2

    Topics: Animals; Arthritis, Experimental; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygena

2001
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
    Bioorganic & medicinal chemistry letters, 2003, Mar-24, Volume: 13, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemi

2003
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.
    Journal of medicinal chemistry, 2003, Sep-11, Volume: 46, Issue:19

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonamides; Binding Sites; Cyclooxygenase

2003
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
    Journal of medicinal chemistry, 2003, Nov-06, Volume: 46, Issue:23

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cyclooxygenase 1; Cyclooxygenase 2;

2003
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
    Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4

    Topics: Adult; Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge

2004
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.
    Journal of medicinal chemistry, 2004, Jul-29, Volume: 47, Issue:16

    Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Isoenzymes; Membrane Pr

2004
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
    Journal of medicinal chemistry, 2006, Mar-09, Volume: 49, Issue:5

    Topics: Administration, Oral; Alkynes; Analgesics; Animals; Arachidonate 15-Lipoxygenase; Carrageenan; Cyclo

2006
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Cyclooxygenase Inhib

2008
Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.
    Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Computer Simulation; Cyclooxygenase 2 Inhibitors; Ede

2008
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
    Bioorganic & medicinal chemistry, 2011, Nov-01, Volume: 19, Issue:21

    Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Cyclooxygenase 2; Cyclooxygenase 2 I

2011
Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents.
    European journal of medicinal chemistry, 2012, Volume: 49

    Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Edema; Models, Mole

2012
Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
    Bioorganic & medicinal chemistry letters, 2017, 07-01, Volume: 27, Issue:13

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Benzimidazoles; C

2017
Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
    European journal of medicinal chemistry, 2019, Nov-15, Volume: 182

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Cyclooxygen

2019
Can L(+)-lactate be used as a marker of experimentally induced inflammation in rats?
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:4

    Topics: Animals; Arthritis, Experimental; Biomarkers; Carrageenan; Cyclooxygenase 2 Inhibitors; Cyclooxygena

2010
Physician-reported management of edema and destabilized blood pressure in cyclooxygenase-2-specific inhibitor users with osteoarthritis and treated hypertension.
    Clinical therapeutics, 2002, Volume: 24, Issue:6

    Topics: Celecoxib; Cross-Sectional Studies; Cyclooxygenase Inhibitors; Diuretics; Edema; Humans; Hypertensio

2002
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
    Pharmacological research, 2002, Volume: 46, Issue:3

    Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal;

2002
Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation.
    British journal of pharmacology, 2002, Volume: 137, Issue:6

    Topics: Animals; Carrageenan; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhib

2002
Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib;

2002
Blood pressure control and rates of edema following the administration of the cyclooxygenase-2 specific inhibitors celecoxib versus rofecoxib in patients with systemic hypertension and osteoarthritis.
    The American journal of cardiology, 2003, May-15, Volume: 91, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Celecoxib; Cycloox

2003
A model analysis of costs of blood pressure destabilization and edema associated with rofecoxib and celecoxib among older patients with osteoarthritis and hypertension in a Medicare Choice population.
    Clinical therapeutics, 2003, Volume: 25, Issue:2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Costs and Cost Analysis; C

2003
Pharmacological characterization of mouse hind paw oedema induced by Bothrops insularis (jararaca ilhoa) snake venom.
    Toxicon : official journal of the International Society on Toxinology, 2003, Volume: 42, Issue:5

    Topics: Animals; Antivenins; Blood Proteins; Bothrops; Crotalid Venoms; Cyclooxygenase Inhibitors; Cyprohept

2003
Studies on the anti-inflammatory effect of fluoxetine in the rat.
    Pharmacological research, 2004, Volume: 49, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyc

2004
Molecular inclusion of rofecoxib with cyclodextrin: pharmacological properties in laboratory animals.
    Die Pharmazie, 2004, Volume: 59, Issue:3

    Topics: Animals; Carrageenan; Cyclodextrins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase I

2004
High frequency of use of rofecoxib at greater than recommended doses: cause for concern.
    Pharmacoepidemiology and drug safety, 2004, Volume: 13, Issue:6

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cross-Sectional Studies

2004
Blood pressure destabilization and edema among 8538 users of celecoxib, rofecoxib, and nonselective nonsteroidal antiinflammatory drugs (NSAID) and nonusers of NSAID receiving ordinary clinical care.
    The Journal of rheumatology, 2004, Volume: 31, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Pressure; Celecox

2004
Lipopolysaccharide-induced paw edema model for detection of cytokine modulating anti-inflammatory agents.
    International immunopharmacology, 2004, Volume: 4, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cells, Cultured; Disease M

2004
Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: involvement of cyclooxygenases and heat shock protein 70.
    World journal of gastroenterology, 2005, Oct-14, Volume: 11, Issue:38

    Topics: Animals; Ceruletide; Cyclooxygenase Inhibitors; Edema; HSP70 Heat-Shock Proteins; Interleukin-1; Int

2005
Characteristics of rofecoxib-polyethylene glycol 4000 solid dispersions and tablets based on solid dispersions.
    Pharmaceutical development and technology, 2005, Volume: 10, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Edema; Female;

2005
Pharmacological separation between peripheral and central functions of cyclooxygenase-2 with CIAA, a novel cyclooxygenase-2 inhibitor.
    European journal of pharmacology, 2006, Jun-06, Volume: 539, Issue:1-2

    Topics: Animals; Brain; Carrageenan; Celecoxib; Chlorobenzoates; Cyclooxygenase 1; Cyclooxygenase 2; Cycloox

2006
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
    European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High

2006
Role of cyclooxygenases in oedema-forming activity of bothropic venoms.
    Toxicon : official journal of the International Society on Toxinology, 2007, Volume: 49, Issue:5

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Blotting, Western; Bothrops; Crotalid Venom

2007
Effects of the selective EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Bone Resorption; Dinoprostone; Dose-Resp

2008
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonate 15-Lipoxygenase; Arachidonic Acid;

1999
Rofecoxib for osteoarthritis and pain.
    The Medical letter on drugs and therapeutics, 1999, Jul-02, Volume: 41, Issue:1056

    Topics: Analgesics; Cyclooxygenase Inhibitors; Diarrhea; Drug Interactions; Dyspepsia; Edema; Enzyme Inhibit

1999
A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents.
    Current medical research and opinion, 2002, Volume: 18, Issue:2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials, Phase II as Topic; Clinic

2002