rofecoxib has been researched along with Colorectal Neoplasms, Hereditary Nonpolyposis in 1 studies
Colorectal Neoplasms, Hereditary Nonpolyposis: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We reported previously that a human colorectal cancer (CRC) cell line, HCA-7, produces significant levels of PGE(2), PGD(2), thromboxane, and PGF(2alpha), but not PGI(2)." | 1.32 | Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. ( Boman, BM; Coffey, RJ; Cutler, NS; Gao, Z; Graves-Deal, R; LaFleur, BJ; Morrow, JD; Terry, E; Whitehead, RH, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cutler, NS | 1 |
| Graves-Deal, R | 1 |
| LaFleur, BJ | 1 |
| Gao, Z | 1 |
| Boman, BM | 1 |
| Whitehead, RH | 1 |
| Terry, E | 1 |
| Morrow, JD | 1 |
| Coffey, RJ | 1 |
1 other study available for rofecoxib and Colorectal Neoplasms, Hereditary Nonpolyposis
| Article | Year |
|---|---|
Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells.
Topics: Apoptosis; Coculture Techniques; Colon; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpo | 2003 |