rofecoxib has been researched along with Cardiomegaly in 4 studies
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rofecoxib also reduced cardiac hypertrophy." | 5.33 | Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats. ( de Champlain, J; Laplante, MA; Wu, R, 2005) |
| "Rofecoxib also reduced cardiac hypertrophy." | 1.33 | Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats. ( de Champlain, J; Laplante, MA; Wu, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Streicher, JM | 1 |
| Kamei, K | 1 |
| Ishikawa, TO | 1 |
| Herschman, H | 1 |
| Wang, Y | 1 |
| Wang, BH | 1 |
| Bertucci, MC | 1 |
| Ma, JY | 1 |
| Adrahtas, A | 1 |
| Cheung, RY | 1 |
| Krum, H | 1 |
| LaPointe, MC | 1 |
| Mendez, M | 1 |
| Leung, A | 1 |
| Tao, Z | 1 |
| Yang, XP | 1 |
| Wu, R | 1 |
| Laplante, MA | 1 |
| de Champlain, J | 1 |
4 other studies available for rofecoxib and Cardiomegaly
| Article | Year |
|---|---|
Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice.
Topics: Animals; Cardiomegaly; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Heart Failure; Heart Ventricle | 2010 |
Celecoxib, but not rofecoxib or naproxen, attenuates cardiac hypertrophy and fibrosis induced in vitro by angiotensin and aldosterone.
Topics: Aldosterone; Angiotensin II; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Car | 2010 |
Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse.
Topics: Animals; Cardiomegaly; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhib | 2004 |
Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiomegaly; Cells, Cult | 2005 |