rofecoxib has been researched along with Brain Ischemia in 7 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The association between rofecoxib use and ischemic stroke has not been shown in clinical trials." | 7.74 | Long-term risk of ischemic stroke associated with rofecoxib. ( Afilalo, J; Coussa-Charley, MJ; Eisenberg, MJ, 2007) |
| " Further, we tested whether the neuronal injury could be ameliorated by intra-ischemic mild hypothermia (33-34 degrees C) alone or in combination with diet treatment of rofecoxib, a COX-2 specific inhibitor." | 7.74 | Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment. ( Pasinetti, G; Thomas, S; Xiang, Z, 2007) |
| " Ischemic stroke was predicted by hypertension, myocardial infarction, low-dose aspirin, comorbidity score, Health Assessment Questionnaire score, and presence of total joint replacement, but not by diabetes, smoking, exercise, or body mass index." | 3.74 | Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: a nested, case-control study. ( Hallenbeck, JM; Michaud, K; Nadareishvili, Z; Wolfe, F, 2008) |
| "The association between rofecoxib use and ischemic stroke has not been shown in clinical trials." | 3.74 | Long-term risk of ischemic stroke associated with rofecoxib. ( Afilalo, J; Coussa-Charley, MJ; Eisenberg, MJ, 2007) |
| " Further, we tested whether the neuronal injury could be ameliorated by intra-ischemic mild hypothermia (33-34 degrees C) alone or in combination with diet treatment of rofecoxib, a COX-2 specific inhibitor." | 3.74 | Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment. ( Pasinetti, G; Thomas, S; Xiang, Z, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ji, B | 1 |
| Kumata, K | 1 |
| Onoe, H | 1 |
| Kaneko, H | 1 |
| Zhang, MR | 1 |
| Seki, C | 1 |
| Ono, M | 1 |
| Shukuri, M | 1 |
| Tokunaga, M | 1 |
| Minamihisamatsu, T | 1 |
| Suhara, T | 1 |
| Higuchi, M | 1 |
| Zhang, Y | 1 |
| Hoda, MN | 1 |
| Zheng, X | 1 |
| Li, W | 1 |
| Luo, P | 1 |
| Maddipati, KR | 1 |
| Seki, T | 1 |
| Ergul, A | 1 |
| Wang, MH | 1 |
| Nadareishvili, Z | 1 |
| Michaud, K | 1 |
| Hallenbeck, JM | 1 |
| Wolfe, F | 1 |
| Andersohn, F | 2 |
| Schade, R | 1 |
| Suissa, S | 1 |
| Garbe, E | 1 |
| Afilalo, J | 1 |
| Coussa-Charley, MJ | 1 |
| Eisenberg, MJ | 1 |
| Xiang, Z | 1 |
| Thomas, S | 1 |
| Pasinetti, G | 1 |
7 other studies available for rofecoxib and Brain Ischemia
| Article | Year |
|---|---|
Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model.
Topics: Animals; Antibodies; Brain; Brain Ischemia; Carbon Radioisotopes; Celecoxib; Cyclooxygenase 2; Disea | 2013 |
Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Ischemia; Cell Line, Tumor; Cell Prol | 2014 |
Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: a nested, case-control study.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; An | 2008 |
Cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs and the risk of ischemic stroke: a nested case-control study.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Case-Control Studi | 2006 |
Long-term risk of ischemic stroke associated with rofecoxib.
Topics: Adenomatous Polyps; Brain Ischemia; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Female; Follo | 2007 |
Cerebrovascular events after discontinuation of rofecoxib treatment.
Topics: Brain Ischemia; Cyclooxygenase 2 Inhibitors; Humans; Incidence; Lactones; Risk; Stroke; Sulfones | 2007 |
Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment.
Topics: Animals; Apoptosis; Brain Ischemia; Carotid Artery, Common; Cerebrovascular Circulation; Cyclooxygen | 2007 |