Page last updated: 2024-11-04

rofecoxib and Asthma

rofecoxib has been researched along with Asthma in 14 studies

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"Aspirin (ASA) and several other nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclo-oxygenase (COX) enzyme both isoforms 1 and 2, and can precipitate asthmatic attacks in aspirin-induced asthmatics."9.12Nasal and bronchial tolerability of Rofecoxib in patients with aspirin induced asthma. ( Dal Negro, R; Guerriero, M; Micheletto, C; Tognella, S, 2006)
"In a subset of patients with asthma, aspirin and several other non-steroidal anti-inflammatory drugs (NSAID) that inhibit simultaneously cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) precipitate dangerous asthmatic attacks."9.09Safety of a specific COX-2 inhibitor in aspirin-induced asthma. ( Bochenek, G; Mejza, F; Nagraba, K; Nizankowska, E; Swierczynska, M; Szczeklik, A, 2001)
"The goal of this study was to determine whether rofecoxib cross-reacts in aspirin-sensitive patients with asthma."9.09Lack of cross-reactivity between rofecoxib and aspirin in aspirin-sensitive patients with asthma. ( Simon, RA; Stevenson, DD, 2001)
"To review the safety of cyclooxygenase-2 (COX-2) inhibitors in asthma patients with aspirin hypersensitivity."8.82Safety of COX-2 inhibitors in asthma patients with aspirin hypersensitivity. ( Fernández, C; West, PM, 2003)
" Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 selective inhibitors such as rofecoxib, induce bronchoconstriction and asthma in sensitive individuals."7.74COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. ( Harrington, LS; Lucas, R; McMaster, SK; Mitchell, JA; Moreno, L; Scadding, G; Warner, TD, 2008)
"In 5 to 10% of adult patients with asthma, aspirin (acetylsalicylic acid [ASA]) and most other nonsteroidal anti-inflammatory drugs (NSAIDs) precipitate acute asthmatic attacks."7.71Safety of a cyclooxygenase-2 inhibitor in patients with aspirin-sensitive asthma. ( Alfaya, T; Berges, P; Camacho, E; García-Rodriguez, R; Hinojosa, M; Iscar, A; Martín-García, C, 2002)
"Aspirin (ASA) and several other nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclo-oxygenase (COX) enzyme both isoforms 1 and 2, and can precipitate asthmatic attacks in aspirin-induced asthmatics."5.12Nasal and bronchial tolerability of Rofecoxib in patients with aspirin induced asthma. ( Dal Negro, R; Guerriero, M; Micheletto, C; Tognella, S, 2006)
" Three subjects with multiple-drug induced urticaria complained of a generalized reaction after challenge (Two due to celecoxib and one due to meloxicam)."5.11Tolerability of three selective cyclo-oxygenase-2 inhibitors, meloxicam, celecoxib and rofecoxib in NSAID-sensitive patients. ( Antonicelli, L; Bilò, MB; Bonadonna, P; Crivellaro, MA; Dama, AR; Schiappoli, M; Senna, G, 2004)
"Aspirin-exacerbated respiratory disease (AERD) is characterized by progressive sinusitis, nasal polyposis, and asthma that begins and continues in the absence of exposure to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs)."5.11Safety of high-dose rofecoxib in patients with aspirin-exacerbated respiratory disease. ( Simon, RA; Stevenson, DD; Woessner, KM, 2004)
"To compare the clinical tolerance to rofecoxib and valdecoxib in patients who previously developed urticaria and angioedema while taking classic NSAIDs."5.11Tolerance of nonsteroidal anti-inflammatory drug-sensitive patients to the highly specific cyclooxygenase 2 inhibitors rofecoxib and valdecoxib. ( Caballero-Fonseca, F; Capriles-Hulett, A; Sánchez-Borges, M, 2005)
"In a subset of patients with asthma, aspirin and several other non-steroidal anti-inflammatory drugs (NSAID) that inhibit simultaneously cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) precipitate dangerous asthmatic attacks."5.09Safety of a specific COX-2 inhibitor in aspirin-induced asthma. ( Bochenek, G; Mejza, F; Nagraba, K; Nizankowska, E; Swierczynska, M; Szczeklik, A, 2001)
"The goal of this study was to determine whether rofecoxib cross-reacts in aspirin-sensitive patients with asthma."5.09Lack of cross-reactivity between rofecoxib and aspirin in aspirin-sensitive patients with asthma. ( Simon, RA; Stevenson, DD, 2001)
"To review the safety of cyclooxygenase-2 (COX-2) inhibitors in asthma patients with aspirin hypersensitivity."4.82Safety of COX-2 inhibitors in asthma patients with aspirin hypersensitivity. ( Fernández, C; West, PM, 2003)
"Selective pharmacological inhibition of COX-2 during the challenge phase worsens airway function in the ovalbumin -induced murine model of acute asthma."3.75[A cyclooxygenase-2 selective inhibitor worsens respiratory function and enhances mast cell activity in ovalbumin-sensitized mice]. ( de Mora, F; Marco, A; Pérez, M; Picado, C; Torres, R, 2009)
" Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 selective inhibitors such as rofecoxib, induce bronchoconstriction and asthma in sensitive individuals."3.74COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. ( Harrington, LS; Lucas, R; McMaster, SK; Mitchell, JA; Moreno, L; Scadding, G; Warner, TD, 2008)
"Rofecoxib appears to be a safe alternative drug among atopic individuals, antibiotic-hypersensitive individuals, and individuals who experienced adverse cutaneous reactions to more than 1 class of NSAIDs, but it is less safe among chronic urticaria patients."3.73Short-term and long-term tolerability of rofecoxib in patients with prior reactions to nonsteroidal anti-inflammatory drugs. ( Colanardi, MC; Ferrannini, A; Nettis, E; Tursi, A, 2005)
"In 5 to 10% of adult patients with asthma, aspirin (acetylsalicylic acid [ASA]) and most other nonsteroidal anti-inflammatory drugs (NSAIDs) precipitate acute asthmatic attacks."3.71Safety of a cyclooxygenase-2 inhibitor in patients with aspirin-sensitive asthma. ( Alfaya, T; Berges, P; Camacho, E; García-Rodriguez, R; Hinojosa, M; Iscar, A; Martín-García, C, 2002)
" One hundred twenty-seven subjects with history of adverse reaction to ASA/NSAIDs received oral challenges with nimesulide, 61 subjects were challenged with meloxicam, 51 subjects were challenged with rofecoxib, and 37 subjects were challenged with all three drugs."2.71Safety of selective COX-2 inhibitors in aspirin/nonsteroidal anti-inflammatory drug-intolerant patients: comparison of nimesulide, meloxicam, and rofecoxib. ( Bavbek, S; Celik, G; Misirligil, Z; Mungan, D; Ozer, F, 2004)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's14 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Harrington, LS1
Lucas, R1
McMaster, SK1
Moreno, L1
Scadding, G1
Warner, TD1
Mitchell, JA1
Torres, R1
Pérez, M1
Marco, A1
Picado, C2
de Mora, F1
Valero, A1
Baltasar, M1
Enrique, E1
Pau, L1
Dordal, MT1
Cisteró, A1
Martí, E1
Inoue, K1
Takano, H1
Kawahito, Y1
Sano, H1
Yoshikawa, T1
West, PM1
Fernández, C1
Bavbek, S1
Celik, G1
Ozer, F1
Mungan, D1
Misirligil, Z1
Senna, G1
Bilò, MB1
Antonicelli, L1
Schiappoli, M1
Crivellaro, MA1
Bonadonna, P1
Dama, AR1
Woessner, KM1
Simon, RA2
Stevenson, DD2
Nettis, E1
Colanardi, MC1
Ferrannini, A1
Tursi, A1
Sánchez-Borges, M1
Caballero-Fonseca, F1
Capriles-Hulett, A1
Micheletto, C1
Tognella, S1
Guerriero, M1
Dal Negro, R1
Szczeklik, A1
Nizankowska, E1
Bochenek, G1
Nagraba, K1
Mejza, F1
Swierczynska, M1
Martín-García, C1
Hinojosa, M1
Berges, P1
Camacho, E1
García-Rodriguez, R1
Alfaya, T1
Iscar, A1

Reviews

1 review available for rofecoxib and Asthma

ArticleYear
Safety of COX-2 inhibitors in asthma patients with aspirin hypersensitivity.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Celecoxib; Cyclooxygenase 2; Drug Hypersen

2003

Trials

7 trials available for rofecoxib and Asthma

ArticleYear
Safety of selective COX-2 inhibitors in aspirin/nonsteroidal anti-inflammatory drug-intolerant patients: comparison of nimesulide, meloxicam, and rofecoxib.
    The Journal of asthma : official journal of the Association for the Care of Asthma, 2004, Volume: 41, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase In

2004
Tolerability of three selective cyclo-oxygenase-2 inhibitors, meloxicam, celecoxib and rofecoxib in NSAID-sensitive patients.
    European annals of allergy and clinical immunology, 2004, Volume: 36, Issue:6

    Topics: Adolescent; Adult; Aged; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Celec

2004
Safety of high-dose rofecoxib in patients with aspirin-exacerbated respiratory disease.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 93, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cross Reactions; Cyclooxygenase Inhibitors

2004
Tolerance of nonsteroidal anti-inflammatory drug-sensitive patients to the highly specific cyclooxygenase 2 inhibitors rofecoxib and valdecoxib.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 94, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Cyclooxygenase Inhibitors

2005
Nasal and bronchial tolerability of Rofecoxib in patients with aspirin induced asthma.
    European annals of allergy and clinical immunology, 2006, Volume: 38, Issue:1

    Topics: Adult; Aspirin; Asthma; Bronchoconstriction; Cyclooxygenase 2 Inhibitors; Female; Forced Expiratory

2006
Safety of a specific COX-2 inhibitor in aspirin-induced asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2001, Volume: 31, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cross-Over Studies; Cyclooxygenase

2001
Lack of cross-reactivity between rofecoxib and aspirin in aspirin-sensitive patients with asthma.
    The Journal of allergy and clinical immunology, 2001, Volume: 108, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cross Reactions; Cyclooxygenase Inhibitors

2001

Other Studies

6 other studies available for rofecoxib and Asthma

ArticleYear
COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:11

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aspirin;

2008
[A cyclooxygenase-2 selective inhibitor worsens respiratory function and enhances mast cell activity in ovalbumin-sensitized mice].
    Archivos de bronconeumologia, 2009, Volume: 45, Issue:4

    Topics: Animals; Asthma; Cyclooxygenase 2 Inhibitors; Lactones; Mast Cells; Mice; Mice, Inbred BALB C; Ovalb

2009
NSAID-sensitive patients tolerate rofecoxib.
    Allergy, 2002, Volume: 57, Issue:12

    Topics: Adolescent; Adult; Aged; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Controlled Cli

2002
Cyclooxygenase-2 inhibitors in aspirin-induced asthma.
    Chest, 2003, Volume: 123, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase 2; Cyclooxygenase 2 Inhibit

2003
Short-term and long-term tolerability of rofecoxib in patients with prior reactions to nonsteroidal anti-inflammatory drugs.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 94, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cyclooxygenase Inhibitors; Drug Hypers

2005
Safety of a cyclooxygenase-2 inhibitor in patients with aspirin-sensitive asthma.
    Chest, 2002, Volume: 121, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase Inhibitors; Fe

2002