rocuronium and Skin-Neoplasms

Cutaneous squamous cell carcinoma (cSCC) is the second-most common type of non-melanoma skin cancer and is linked to long-term exposure to ultraviolet (UV) radiation from the sun. Rocuronium bromide (RocBr) is an FDA-approved drug that targets p53-related protein kinase (PRPK) that inhibits the development of UV-induced cSCC. This study aimed to investigate the physicochemical properties and in vitro behavior of RocBr. Techniques such as thermal analysis, electron microscopy, spectroscopy and in vitro assays were used to characterize RocBr. A topical oil/water emulsion lotion formulation of RocBr was successfully developed and evaluated. The in vitro permeation behavior of RocBr from its lotion formulation was quantified with Strat-M

Topics: Carcinoma, Squamous Cell; Cell Culture Techniques; Humans; Pharmaceutical Preparations; Rocuronium; Skin; Skin Neoplasms

Solar ultraviolet (sUV) irradiation is a major environmental carcinogen that can cause inflammation and skin cancer. The costs and morbidity associated with skin cancer are increasing, and therefore identifying molecules that can help prevent skin carcinogenesis is important. In this study, we identified the p53-related protein kinase (PRPK) as a novel oncogenic protein that is phosphorylated by the T-LAK cell-originated protein kinase (TOPK). Knockdown of TOPK inhibited PRPK phosphorylation and conferred resistance to solar-simulated light (SSL)-induced skin carcinogenesis in mouse models. In the clinic, acute SSL irradiation significantly increased epidermal thickness as well as total protein and phosphorylation levels of TOPK and PRPK in human skin tissues. We identified two PRPK inhibitors, FDA-approved rocuronium bromide (Zemuron

Topics: Animals; Betamethasone Valerate; Carcinogenesis; Carcinoma, Squamous Cell; Enzyme Inhibitors; Humans; Mice; Mice, Hairless; Mitogen-Activated Protein Kinase Kinases; Protein Serine-Threonine Kinases; Rocuronium; Skin Neoplasms; Ultraviolet Rays

Topics: Adolescent; Adult; Amoxicillin-Potassium Clavulanate Combination; Androstanols; Anemia; Anesthesia; Anesthetics, Inhalation; Antibiotic Prophylaxis; Blood Transfusion; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Child; Child, Preschool; Dermatologic Surgical Procedures; Female; Humans; Laryngeal Masks; Male; Methyl Ethers; Monitoring, Intraoperative; Neuromuscular Nondepolarizing Agents; Postoperative Complications; Prospective Studies; Rocuronium; Sevoflurane; Skin Neoplasms; Xeroderma Pigmentosum; Young Adult