rocuronium and Diabetes-Mellitus

To determine the infusion rates that maintain the train-of-four (TOF) ratio within 20-70% in dogs and compare the infusion rates between diabetic and nondiabetic dogs.. Prospective clinical study.. In total, 47 dogs scheduled for phacoemulsification were included with a median (80% central range) bodyweight of 10.6 (5.7-35.5) kg and age of 7 (1-11) years. Diabetes mellitus was previously diagnosed in nine dogs.. After premedication using acepromazine and methadone, anaesthesia was induced by intravenous (IV) propofol and maintained by isoflurane and fentanyl or remifentanil. The TOF ratio was monitored by stimulating the peroneal nerve and the response quantified by accelerometry. Rocuronium 0.5 mg kg. A stable infusion rate was found in 42 dogs. A higher median (80% central range) infusion rate was found in diabetic [0.43 (0.35-0.50) mg kg. There is a quite large individual variation in the infusion rates of rocuronium needed to maintain a stable neuromuscular block in a varied population of dogs. Of the variables investigated, diabetes mellitus was the only one found to significantly influence the infusion rate of rocuronium.

Topics: Anesthesia; Animals; Diabetes Mellitus; Dog Diseases; Dogs; Infusions, Intravenous; Neuromuscular Nondepolarizing Agents; Pain Measurement; Phacoemulsification; Rocuronium