rocuronium and Carcinoma--Squamous-Cell

Cutaneous squamous cell carcinoma (cSCC) is the second-most common type of non-melanoma skin cancer and is linked to long-term exposure to ultraviolet (UV) radiation from the sun. Rocuronium bromide (RocBr) is an FDA-approved drug that targets p53-related protein kinase (PRPK) that inhibits the development of UV-induced cSCC. This study aimed to investigate the physicochemical properties and in vitro behavior of RocBr. Techniques such as thermal analysis, electron microscopy, spectroscopy and in vitro assays were used to characterize RocBr. A topical oil/water emulsion lotion formulation of RocBr was successfully developed and evaluated. The in vitro permeation behavior of RocBr from its lotion formulation was quantified with Strat-M

Topics: Carcinoma, Squamous Cell; Cell Culture Techniques; Humans; Pharmaceutical Preparations; Rocuronium; Skin; Skin Neoplasms

Solar ultraviolet (sUV) irradiation is a major environmental carcinogen that can cause inflammation and skin cancer. The costs and morbidity associated with skin cancer are increasing, and therefore identifying molecules that can help prevent skin carcinogenesis is important. In this study, we identified the p53-related protein kinase (PRPK) as a novel oncogenic protein that is phosphorylated by the T-LAK cell-originated protein kinase (TOPK). Knockdown of TOPK inhibited PRPK phosphorylation and conferred resistance to solar-simulated light (SSL)-induced skin carcinogenesis in mouse models. In the clinic, acute SSL irradiation significantly increased epidermal thickness as well as total protein and phosphorylation levels of TOPK and PRPK in human skin tissues. We identified two PRPK inhibitors, FDA-approved rocuronium bromide (Zemuron

Topics: Animals; Betamethasone Valerate; Carcinogenesis; Carcinoma, Squamous Cell; Enzyme Inhibitors; Humans; Mice; Mice, Hairless; Mitogen-Activated Protein Kinase Kinases; Protein Serine-Threonine Kinases; Rocuronium; Skin Neoplasms; Ultraviolet Rays

Topics: Adolescent; Adult; Amoxicillin-Potassium Clavulanate Combination; Androstanols; Anemia; Anesthesia; Anesthetics, Inhalation; Antibiotic Prophylaxis; Blood Transfusion; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Child; Child, Preschool; Dermatologic Surgical Procedures; Female; Humans; Laryngeal Masks; Male; Methyl Ethers; Monitoring, Intraoperative; Neuromuscular Nondepolarizing Agents; Postoperative Complications; Prospective Studies; Rocuronium; Sevoflurane; Skin Neoplasms; Xeroderma Pigmentosum; Young Adult

A 53-year-old man with hypopharyngeal stenosis following curative chemoradiotherapy for a tongue base tumour presented three years later for an attempt at pharyngeal dilatation. The first attempt 6 months previously was abandoned when awake fibreoptic intubation failed due to partial airway obstruction and desaturation when the fibrescope was advanced. As mask ventilation was anticipated to be possible, a further attempt at intubation after induction of anaesthesia was judged appropriate. The backup plan was jet ventilation via a cricothyroid cannula sited pre-induction. However, neither mask nor jet ventilation proved possible after the induction of anaesthesia and neuromuscular blockade with rocuronium. Swift administration of sugammadex on a background of thorough pre-oxygenation allowed return of spontaneous breathing before the development of hypoxia and so avoided the need for surgical airway rescue. This case demonstrates the utility of sugammadex in restoring spontaneous respiration in a 'can't ventilate' scenario, provided that the airway has not been traumatised by instrumentation.

Topics: Airway Management; Airway Obstruction; Androstanols; Carcinoma, Squamous Cell; Constriction, Pathologic; Cricoid Cartilage; Dilatation; gamma-Cyclodextrins; Humans; Hypopharynx; Intubation, Intratracheal; Male; Middle Aged; Neuromuscular Nondepolarizing Agents; Rocuronium; Sugammadex; Tongue Neoplasms

Topics: Aged, 80 and over; Androstanols; Anesthesia, Intravenous; Anesthetics, Intravenous; Carcinoma, Squamous Cell; Delayed Emergence from Anesthesia; Dermatomyositis; Disease Susceptibility; Female; Humans; Intraoperative Complications; Neuromuscular Nondepolarizing Agents; Parathyroid Neoplasms; Parathyroidectomy; Piperidines; Pneumonia, Aspiration; Preanesthetic Medication; Propofol; Remifentanil; Risk; Rocuronium