rocaglamide and Breast-Neoplasms

rocaglamide has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for rocaglamide and Breast-Neoplasms

Article	Year
Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase. Journal of medicinal chemistry, 2020, 06-11, Volume: 63, Issue:11 Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent protein synthesis. The flavagline class of natural products ( Topics: Animals; Benzofurans; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Eukaryotic Initiation Factor-4A; Female; Half-Life; Humans; Ligands; Mice; Mice, Nude; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Rats; RNA, Messenger; Structure-Activity Relationship	2020

Article

Year

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.

Journal of medicinal chemistry, 2020, 06-11, Volume: 63, Issue:11

Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent protein synthesis. The flavagline class of natural products (

Topics: Animals; Benzofurans; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Eukaryotic Initiation Factor-4A; Female; Half-Life; Humans; Ligands; Mice; Mice, Nude; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Rats; RNA, Messenger; Structure-Activity Relationship

2020