ro13-9904 and Uveitis--Posterior

Report of clinical/multimodal imaging outcomes of patients with syphilitic uveitis alternatively treated with intravenous(IV) ceftriaxone, due to unavailability of penicillin G.. Chart review of all cases of syphilitic uveitis presenting to Hospital São Geraldo/HC-UFMG and treated with intravenous ceftriaxone, between January and August 2014. Clinical, serological and ophthalmological data were collected.. Twelve consecutive patients with syphilitic uveitis receiving IV ceftriaxone were identified. All 24 eyes had active intraocular inflammation on clinical examination. All patients received IV ceftriaxone (2-4 g daily) for 14-21 days, supplemented with oral corticosteroid as needed in 9 patients (75%), after documented clinical response. Improvement in intraocular inflammation was seen in all 24 eyes, with median best-corrected visual acuity (BCVA) increasing from 20/50 to 20/20, after a mean follow-up of 5.3 months.. IV ceftriaxone may be an effective alternative for treatment of syphilitic uveitis, in the setting of unavailability of penicillin G.

Topics: Administration, Oral; Adult; Aged; Anti-Bacterial Agents; Ceftriaxone; Chorioretinitis; Complementary Therapies; Eye Infections, Bacterial; Fluorescein Angiography; Glucocorticoids; Humans; Infusions, Intravenous; Male; Middle Aged; Multimodal Imaging; Retrospective Studies; Syphilis; Syphilis Serodiagnosis; Tomography, Optical Coherence; Uveitis, Posterior; Visual Acuity