ro13-9904 and Spinal-Diseases

A previously healthy male with subacute onset right leg weakness was suspected to have an astrocytoma as imaging showed a lesion. Subsequent biopsy showed the presence of foamy macrophages containing periodic acid-Schiff staining granules, suggesting Whipple disease as a possible diagnosis.

Topics: Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Duodenum; Foam Cells; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Periodic Acid-Schiff Reaction; Recurrence; Spinal Diseases; Trimethoprim, Sulfamethoxazole Drug Combination; Tropheryma; Whipple Disease

The purpose of this study was to review a case comprised of a cervical spinal epidural abscess, cervical and thoracic paraspinous edema, and widening of the right thoracic neural foramen secondary to a phlegmon.. We reviewed the case of a spinal epidural abscess managed medically in a 4-year-old male and performed a review of the literature with 15 other cases that have previously been reported.. The current mainstay of treatment is largely variant but generally falls into a laminectomy-based surgical approach or longstanding antibiotics. Our review of the literature concluded that there are currently no clear guidelines established to recommend treatment, and current practice is largely based on the discretion of the pediatric neurosurgeon.. Based on the literature review, and our personal case illustration, we conclude that an antibiotic-based treatment is a valid approach for therapy if initiated promptly in a pediatric patient with no neurological deficit.

Topics: Anti-Bacterial Agents; Ceftriaxone; Cellulitis; Child, Preschool; Daptomycin; Edema; Epidural Abscess; Humans; Magnetic Resonance Imaging; Male; Spinal Diseases; Treatment Outcome

To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis.. Interventional case report.. A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration. A history of recent eye trauma was reported.. Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants.. Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.

Topics: Antigens, CD; Antigens, CD1; Antigens, Differentiation, Myelomonocytic; Ceftriaxone; Cellulitis; Child, Preschool; Combined Modality Therapy; Female; Histiocytosis, Langerhans-Cell; Humans; Immunohistochemistry; Orbital Diseases; S100 Proteins; Spinal Diseases; Tomography, X-Ray Computed; Vimentin

Topics: Anti-Bacterial Agents; Atlanto-Axial Joint; Ceftriaxone; Epidural Abscess; Humans; Joint Instability; Magnetic Resonance Imaging; Male; Middle Aged; Osteomyelitis; Radiography; Spinal Diseases; Syndrome

Topics: Abscess; Adult; Analgesia, Epidural; Anti-Bacterial Agents; Catheters, Indwelling; Ceftriaxone; Cephalosporins; Drug Therapy, Combination; Epidural Space; Female; Humans; Lumbar Vertebrae; Magnetic Resonance Imaging; Spinal Diseases; Vancomycin

Topics: Adult; Ceftriaxone; Haemophilus Infections; Humans; Male; Osteomyelitis; Spinal Diseases