ro13-9904 and Skin-Neoplasms

Topics: Aged, 80 and over; Anti-Bacterial Agents; Antigens, CD20; Borrelia burgdorferi Group; Ceftriaxone; Cell Differentiation; Europe; Female; Humans; Lyme Disease; Lymphocytes; Lymphoma; Plasma Cells; Polymerase Chain Reaction; Skin Neoplasms

A 60-years old female patient developed juxta-articular fibroid nodules and erythrocyanotic lesions of acrodermatitis chronica atrophicans after several tick bites. The woman was treated with ceftriaxon (Rocephin) 2 g daily parenterally without adverse reactions.

Topics: Acrodermatitis; Ceftriaxone; Elbow Joint; Erythema Chronicum Migrans; Female; Fibroma; Humans; Infusions, Intravenous; Knee Joint; Lyme Disease; Middle Aged; Skin; Skin Neoplasms

Clinical manifestations of Lyme disease are mainly cutaneous, neurologic, cardiac and/or located joints. Some dermatologic manifestations are more specific.. An eight year-old-girl was examined because she suffered from a nodular lesion located on the left breast areola which appeared 3 months earlier. This lesion was associated with an expanding erythematous annular lesion located on the anterior face of thorax and left axillary area, without any lymphadenopathy. The association of this cutaneous lymphocytoma and erythema chronicum migrans was suggestive of Borellia infection despite absence of previous tick bite. Serologic tests (indirect immunofluorescence) were negative, but both lesions disappeared within 2 weeks with ceftriaxone, 50 mg/kg/day.. This association is pathognomonic of Lyme disease; serologic tests may be found negative in the early stages of disease.

Topics: Breast; Breast Neoplasms; Ceftriaxone; Child; Erythema Chronicum Migrans; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lyme Disease; Nipples; Skin Neoplasms