ro13-9904 and Retinal-Detachment

Vancomycin (25 mg), ceftriaxone (125 mg), and ceftazidime (100 mg) were given by subconjunctival injection before vitrectomy to patients with uninfected eyes. Most of the patients had diabetic vitreous hemorrhage with or without traction retinal detachments, and some had rhegmatogenous retinal detachments with proliferative vitreoretinopathy. Samples of vitreous were obtained by pars plana vitrectomy at intervals from 46 minutes to 4 hours 13 minutes after the subconjunctival injection. The median vitreous concentrations of all three drugs were below the limit of detection. Vitreous concentrations of these drugs after a single subconjunctival injection are exceedingly low.

Topics: Adult; Aged; Aged, 80 and over; Ceftazidime; Ceftriaxone; Conjunctiva; Female; Humans; Injections; Male; Middle Aged; Retinal Detachment; Vancomycin; Vitrectomy; Vitreous Body; Vitreous Hemorrhage

Intraocular inflammations as chief manifestation of a T. pallidum infection associated with stage II syphilis are rarely documented in the recent literature. We report on a 35 year old patient with bilateral choroiditis, retinal vasculitis and papillitis persisting retrospectively since he had received some medication for syphilis 8 years previously. This patient was at high risk for other sexually transmitted diseases, however, he did not show HIV-seroconversion. General symptoms like uneasiness, fatigue, depressions and intermittent weight loss were mentioned. Reduction of visual acuity with topical corticosteroid therapy led to another medical work-up, and a systemic therapy with Ceftriaxone for 14 days resulted in better vision, better perimetric results and less inflammatory cell in the vitreous but evident optic atrophy.

Topics: Adult; Ceftriaxone; Chorioretinitis; Drug Therapy, Combination; Follow-Up Studies; Humans; Male; Methylprednisolone; Neurosyphilis; Papilledema; Retinal Detachment; Syphilis Serodiagnosis; Visual Acuity; Visual Fields