ro13-9904 and Orbital-Pseudotumor

To determine the frequency and dependence of Lyme borreliosis after tick infestation in the eyelid region.. Five patients after tick inoculation were investigated by immunofluorescence assays for IgM and IgG system). Ophthalmologic evaluation of myositis was supported with MRI, laboratory, and internal clinical investigations.. Four children showed negative Borrelia serology after a bite from a tick. In one case the left abducens nerve palsy was found, which was diagnosed in MRI as a thickened left lateral rectus muscle. The diagnosis of myositis with positive Borrelia burgdorferi serology was consistent with Lyme borreliosis. Other laboratory examinations were negative. The symptoms were reduced after treatment with ceftriaxon.. Lyme borreliosis was found in one in five patients after tick infestation in the eyelid region. Antibiotic prophylaxis against Lyme borreliosis with ampicillin is recommended for children after a tick bite.

Topics: Animals; Bites and Stings; Borrelia burgdorferi Group; Ceftriaxone; Child; Child, Preschool; Eyelids; Humans; Lyme Disease; Oculomotor Muscles; Orbital Pseudotumor; Serologic Tests; Tick Infestations; Ticks

To report on the clinical findings in a patient with isolated left inferior rectus myositis associated with serologically confirmed Borrelia burgdorferi infection.. Interventional case report.. Comprehensive clinical, laboratory, and imaging evaluation.. Contrast-enhanced computed tomography showed a swollen inferior rectus muscle with infraorbital soft tissue swelling in a patient with diplopia and prior symptoms consistent with manifestations of Lyme disease. Positive serum and cerebrospinal fluid antibodies to B. burgdorferi by enzyme-linked immunoassay were confirmed by Western blot, and the cerebrospinal fluid/serum antibody ratio was elevated. No alternative cause for orbital myositis was found, and treatment with antibiotics resulted in a complete recovery.. Orbital myositis should be added to the expanding list of ophthalmic manifestations of Lyme disease. Correct diagnosis and appropriate antibiotic therapy may reduce the likelihood of further neurologic or ophthalmologic sequelae.

Topics: Adult; Anti-Bacterial Agents; Antibodies, Bacterial; Blotting, Western; Borrelia burgdorferi; Ceftriaxone; Diplopia; Enzyme-Linked Immunosorbent Assay; Eye Infections, Bacterial; Humans; Lyme Disease; Male; Oculomotor Muscles; Orbital Pseudotumor; Tomography, X-Ray Computed