ro13-9904 and Muscle-Weakness

Topics: Ceftriaxone; Epidural Abscess; Humans; Klebsiella Infections; Klebsiella pneumoniae; Leg; Male; Mastoidectomy; Middle Aged; Muscle Weakness; Surgical Wound Infection; Vancomycin

There are few reports of in vivo muscle strength measurements in animal models of ICU-acquired weakness (ICU-AW). In this study we investigated whether the Escherichia coli (E. coli) septic peritonitis mouse model may serve as an ICU-AW model using in vivo strength measurements and myosin/actin assays, and whether development of ICU-AW is age-dependent in this model.. Young and old mice were injected intraperitoneally with E. coli and treated with ceftriaxone. Forelimb grip strength was measured at multiple time points, and the myosin/actin ratio in muscle was determined.. E. coli administration was not associated with grip strength decrease, neither in young nor in old mice. In old mice, the myosin/actin ratio was lower in E. coli mice at t = 48 h and higher at t = 72 h compared with controls.. This E. coli septic peritonitis mouse model did not induce decreased grip strength. In its current form, it seems unsuitable as a model for ICU-AW.

Topics: Actins; Age Factors; Aging; Animals; Anti-Bacterial Agents; Body Weight; Ceftriaxone; Disease Models, Animal; Escherichia coli; Intensive Care Units; Male; Mice; Mice, Inbred C57BL; Muscle Weakness; Muscle, Skeletal; Myosins; Peritonitis

Topics: Acyclovir; Adolescent; Anti-Bacterial Agents; Antiviral Agents; Ceftriaxone; Cough; Diagnosis, Differential; Disorders of Excessive Somnolence; Encephalomyelitis, Acute Disseminated; Fever; Humans; Male; Muscle Weakness

An 84-year old woman came to the emergency department with sharp back pain on her left side that she'd had for 4 days. The pain radiated to her posterior hips when standing. She said her whole body felt achy and she was experiencing weakness in both legs.

Topics: Aged, 80 and over; Anti-Bacterial Agents; Back Pain; Ceftriaxone; Diagnosis, Differential; Female; Humans; Intervertebral Disc Degeneration; Muscle Weakness; Osteomyelitis; Streptococcal Infections; Streptococcus

Topics: Anti-Bacterial Agents; Brachial Plexus Neuritis; Brachial Plexus Neuropathies; Ceftriaxone; Diagnosis, Differential; Female; Humans; Lyme Neuroborreliosis; Magnetic Resonance Imaging; Middle Aged; Motor Neuron Disease; Muscle Weakness; Paralysis

Perineuritis is an unusual cause of direct peripheral nerve injury. We describe the clinicopathologic features of a 56-year-old man with mononeuritis multiplex due to Lyme disease; sural nerve biopsy demonstrated florid perineuritis. Treatment with intravenous ceftriaxone resulted in marked neurologic improvement. This study supports the notion that perineuritis forms part of the pathogenesis in acute Lyme neuroborreliosis.

Topics: Anti-Bacterial Agents; Arm; Axons; Biopsy; Ceftriaxone; Chemotaxis, Leukocyte; Humans; Immunosuppressive Agents; Leg; Lyme Neuroborreliosis; Male; Methylprednisolone; Middle Aged; Muscle Weakness; Neuritis; Peripheral Nerves; Sural Nerve; Treatment Outcome; Wallerian Degeneration

This is a report of 2 patients with Lyme disease who initially presented with severe constipation, which progressed to ascending muscular weakness resembling acute idiopathic polyneuritis, with neuropsychiatric symptoms, severe urinary retention, and hyponatremia. These symptoms resolved following proper antibiotic therapy.

Topics: Aged; Anti-Bacterial Agents; Antibodies, Bacterial; Ceftriaxone; Constipation; Depression; Hallucinations; Humans; Hyponatremia; Lyme Neuroborreliosis; Male; Mental Disorders; Middle Aged; Muscle Weakness; Serologic Tests; Treatment Outcome; Urination Disorders