ro13-9904 and Macrophage-Activation-Syndrome

Macrophage activation syndrome (MAS) is a rare life-threatening condition characterized by cytokine-mediated tissue injury and multiorgan dysfunction.. We describe the unique case of young man who developed MAS as the sole manifestation of an otherwise paucisymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.. Clinical and biological criteria led to the diagnosis of MAS; cytokine profile was highly suggestive reverse transcription polymerase chain reaction for SARS-CoV-2 in nasopharyngeal swabs was negative, but serum anti-SARS-CoV-2 immunoglobulin A and immunoglobulin G resulted positive leading to the diagnosis of SARS-CoV-2 infection.. The patient was treated with empiric antibiotic and hydroxychloroquine.. Clinical improvement ensued. At follow-up, the patient is well.. SARS-CoV-2 infection may trigger develop life-threatening complications, like MAS. This can be independent from coronavirus disease 2019 gravity.

Topics: Adolescent; Blood Chemical Analysis; Ceftriaxone; China; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Testing; Diagnosis, Differential; Disease Progression; DNA, Viral; Drug Therapy, Combination; Electrocardiography; Follow-Up Studies; Hospitalization; Humans; Hydroxychloroquine; Macrophage Activation Syndrome; Male; Pandemics; Patient Discharge; Pneumonia, Viral; Radiography, Thoracic; Real-Time Polymerase Chain Reaction; Risk Assessment; Severity of Illness Index; Tomography, X-Ray Computed; Treatment Outcome