ro13-9904 and Klinefelter-Syndrome

A case is reported of prosthetic valve endocarditis due to Neisseria elongata subsp. elongata in a patient with Klinefelter's syndrome. This is believed to be only the third case of endocarditis reported due to this subspecies. N. elongata is difficult to identify, and is morphologically and biochemically similar to Kingella spp. Sequencing of the 16S rRNA gene is useful for identification. The patient was successfully treated with amoxicillin and gentamicin, followed by ceftriaxone.

Topics: Aged; Amoxicillin; Ceftriaxone; Diagnosis, Differential; DNA, Bacterial; DNA, Ribosomal; Endocarditis, Bacterial; Gentamicins; Heart Valve Prosthesis; Humans; Kingella; Klinefelter Syndrome; Male; Molecular Sequence Data; Neisseria elongata; Neisseriaceae Infections; Prosthesis-Related Infections; RNA, Ribosomal, 16S; Sequence Analysis, DNA