ro13-9904 and Kidney-Neoplasms

This monocentric prospective randomized study was designed to determine the efficacy of single-shot perioperative antibiotic prophylaxis with 1 g ceftriaxone i.v. in transperitoneal tumor nephrectomy. Eighty-three patients were randomized either into a prophylaxis or a control group: 39 patients received 1 g ceftriaxone i.v. 30 min preoperatively and 44 no study medication. Characteristics of the two groups showed no statistical differences. Postoperative overall infection rates were 7.7% and 27.3% (p=0.007), respectively. Postoperative assessment revealed overall 0 (0%)/7 (15.9%) wound infections, 0 (0%)/2 (4.5%) deep wound infections, 1 (2.6%)/2 (4.5%) pneumoniae, and 2 (5.2%)/3 (6.8%) significant urinary tract infections. In 4 (10.3%)/4 (9.1%) patients, postoperative antibiosis was started without detection of an infectious focus. Overall antibiotic treatment was carried out in 7 (17.9%)/12 (27.3%) patients postoperatively. Costs of antibiotic prophylaxis and/or treatment resulted in 23.60/30.10ZZZ;EUR per patient. Perioperative prophylaxis with 1 g ceftriaxone i.v. decreases postoperative infection rates. Although not all infections have to be treated with antibiotics, there are pharmacoeconomic advantages of such prophylaxis.

Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Ceftriaxone; Comorbidity; Cross Infection; Cross-Sectional Studies; Female; Humans; Incidence; Infusions, Intravenous; Kidney Neoplasms; Male; Middle Aged; Nephrectomy; Pneumonia, Bacterial; Prospective Studies; Risk Factors; Sepsis; Surgical Wound Infection; Treatment Outcome; Urinary Tract Infections

Topics: Analgesia, Epidural; Anti-Bacterial Agents; Back Pain; Carcinoma, Renal Cell; Ceftriaxone; Fatal Outcome; Humans; Kidney Neoplasms; Male; Meningitis, Bacterial; Middle Aged; Palliative Care; Paraplegia; Urinary Retention