ro13-9904 has been researched along with Hypoalbuminemia* in 2 studies
2 other study(ies) available for ro13-9904 and Hypoalbuminemia
| Article | Year |
|---|---|
Ceftriaxone Dosing in a Critically Ill Patient With Hypoalbuminemia During Continuous Venous Hemofiltration: Emphasis on Unbound Pharmacokinetics.
Topics: Aged; Anti-Bacterial Agents; Ceftriaxone; Critical Illness; Escherichia coli Infections; Female; Hemofiltration; Humans; Hypoalbuminemia; Shock, Septic | 2020 |
Comparative Plasma Pharmacokinetics of Ceftriaxone and Ertapenem in Normoalbuminemia, Hypoalbuminemia, and Albumin Replacement in a Sheep Model.
Optimal concentrations of unbound antimicrobials are essential for a maximum microbiological effect. Although hypoalbuminemia and albumin fluid resuscitation are common in critical care, the effects of different albumin concentrations on the unbound concentrations of highly protein-bound antimicrobials are not known. The aim of this study was to compare the effects of different albumin states on total and unbound concentrations of ertapenem and ceftriaxone using an ovine model. The study design was a prospective, three-phase intervention observational study. The subjects were healthy Merino sheep. Eight sheep were subjected to three experimental phases: normoalbuminemia, hypoalbuminemia using plasmapheresis, and albumin replacement using a 25% albumin solution. In each phase, ceftriaxone at 40 mg/kg of body weight and ertapenem at 15 mg/kg were given intravenously. Blood samples were collected at predefined intervals and analyzed using an ultrahigh-performance liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters such as the area under the curve from 0 to 24 h (AUC Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Ertapenem; Hypoalbuminemia; Pharmaceutical Preparations; Prospective Studies; Sheep | 2020 |