ro13-9904 and Head-and-Neck-Neoplasms

In this random study, 60 patients were given either cefotaxime, or ceftriaxone as a prophylactic measure in cervicofacial surgery. Each antibiotic was administered during a 48-hour period starting 1 h before the operation. Twenty-three patients underwent major cervicofacial surgery including opening of the pharynx or the buccal cavity by the cervical route. Only a single postoperative infection was observed as a result of a salivary fistula on the 2nd postoperative day. The two antibiotics have turned out to be very efficient as short-term prophylactic treatment in cervicofacial surgery. In other respects, the much longer half-life of ceftriaxone means that a single daily dose can be given. Finally, the cost of the prophylactic treatment is smaller using ceftriaxone than cefotaxime.

Topics: Adult; Cefotaxime; Ceftriaxone; Clinical Trials as Topic; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Random Allocation; Surgical Wound Infection

In our work we have considered the problems related to the post-operative hospitalization in patients admitted to our ENT's department in the last 4 years.. Our observations refer to a sample of 155 patients suffering from head and neck tumors.. Regarding therapy, some drugs have been less effective to prevent post-operative infection: the ceftriaxone at the level of the oral cavity/oropharynx and ceftriaxone/pefloxacin at the level of the hypopharynx/larynx.. Post-operative infections in cancer surgery can compromise not only the surgical outcome but also be responsible for delays for any adjuvant treatments. Post-operative infections risk in head-neck cancer surgery drops from 30- 80 % to 20 % with perioperative antibiotic prophylaxis. Despite the introduction of pre-operative prophylaxis , according to guidelines, the number of post-surgical infections still remains high (40/61% of cases). It is important to know the intrinsic risk factors (related to the patient) and extrinsic (related to the external environment and the same procedure) to better understand how to prevent infections. Prolonged hospitalization can expose patients to the risk of hospital pathogens.. We tried to outline a profile of head-neck cancer patients more likely to contract post-operative infections. We also compared the effects of various antibiotics administered before and after the onset of complications to suggest a therapeutic protocol.. Antibiotics therapy Post-operative infectious, Prophylaxis in head and neck surgery.. Le infezioni post-operatorie nella chirurgia oncologica possono compromettere non solo l’esito chirurgico ma anche essere responsabili di ritardi per eventuali trattamenti adiuvanti. I rischi di infezioni postoperatorie nella chirurgia del cancro della testa-collo scendono dal 30- 80% al 20% con la profilassi antibiotica perioperatoria. Nonostante l’introduzione, come da linee guida, della profilassi preoperatoria, il numero di infezioni postchirurgiche rimane ancora elevato (40/61% dei casi). È importante conoscere i fattori di rischio intrinseci (legati al paziente) ed estrinseci (legati all’ambiente esterno e alla stessa procedura) per capire meglio come prevenire le infezioni. Il ricovero prolungato può esporre i pazienti al rischio di agenti patogeni ospedalieri. Nel nostro lavoro abbiamo considerato le problematiche legate al ricovero post-operatorio nei pazienti degenti presso il nostro reparto ORL negli ultimi 4 anni. Abbiamo cercato di delineare un profilo di pazienti con carcinoma del distretto testa-collo che hanno maggiori probabilità di contrarre infezioni post-operatorie. Abbiamo anche confrontato gli effetti di vari antibiotici somministrati prima e dopo l’insorgenza delle complicanze per suggerire un protocollo terapeutico.

Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Ceftriaxone; Head and Neck Neoplasms; Humans; Postoperative Complications; Surgical Wound Infection