ro13-9904 and Exophthalmos

Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Cornea; Endophthalmitis; Exophthalmos; Eyelids; Gentamicins; Humans; Intracranial Hemorrhages; Male; Serratia Infections; Serratia marcescens; Tomography, X-Ray Computed; Unconsciousness

Whipple's disease is a systemic disorder caused by an infection with a gram-positive bacillus, Tropheryma whipplei. Almost every organ system can be affected in Whipple's disease, resulting in varying clinical symptoms.. As far as we are aware, this report of a 61-year-old male is the first presenting with a periorbital manifestation of the disease, with severe exophthalmos and optic nerve involvement, leading to rapid visual loss. This emergency case was successfully treated by a surgical orbital decompression combined with systemic use of antibiotics and steroids.. Whipple's disease can affect the periorbital tissues and the optic nerve, causing massive exophthalmos and serious transient visual loss. In such a case surgical decompression of the affected orbit combined with antibiotics and steroids is a recommended valid treatment option.

Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Decompression, Surgical; Exophthalmos; Humans; Male; Metronidazole; Middle Aged; Nerve Compression Syndromes; Optic Nerve Diseases; Orbital Diseases; Vision Disorders; Whipple Disease

Topics: Aged; Anti-Infective Agents; Cavernous Sinus Thrombosis; Ceftriaxone; Cephalosporins; Combined Modality Therapy; Diplopia; Drainage; Drug Therapy, Combination; Exophthalmos; Humans; Male; Metronidazole; Nafcillin; Ophthalmoplegia; Penicillins; Periodontal Abscess; Pseudomonas Infections; Retropharyngeal Abscess; Tomography, X-Ray Computed