ro13-9904 and Esophageal-Diseases

Actinomycotic infections involving the oesophagus are uncommon but have been reported in both immunocompromised and immunocompetent individuals. We report a case of actinomycosis oesophagitis in a patient with lung cancer who received chemo- and radiotherapy. This patient was admitted with severe dysphagia and odynophagia and biopsy from an oesophageal ulcer found on oesophagogastroduodenoscopy (EGD) revealed actinomycosis. The patient was treated with intravenous penicillin G followed by ceftriaxone with clinical improvement and repeat EGD showed reduction in the size of the oesophageal ulcer, but he relapsed due to non-compliance. We review the English literature regarding the clinical features, diagnosis, and management of actinomycotic infections of the oesophagus.

Topics: Actinomyces; Actinomycosis; Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Endoscopy, Digestive System; Esophageal Diseases; Esophagus; Humans; Male; Middle Aged; Penicillin G; Recurrence; Treatment Outcome; Treatment Refusal; Ulcer