ro13-9904 and Erysipelothrix-Infections

We report here an atypical case of acute sacroiliitis caused by

Topics: Animals; Ceftriaxone; Ciprofloxacin; Endocarditis; Erysipelothrix; Erysipelothrix Infections; Female; Humans; Middle Aged; Sacroiliitis

Because of the increasing number of renal transplantations performed and the rarity of reported cases of infective endocarditis in these patients, we studied the clinical characteristics of this infection in this population. We report on two cases from our experience and review reported cases of infective endocarditis in renal transplant recipients retrieved from the MEDLINE system. In addition, we reviewed a large series of infective endocarditis looking for patients with renal transplants. In addition to our 2 cases, 12 previously reported cases were found. The mean time from transplantation to diagnosis of infective endocarditis was 3.5 years (range 2 months to 15 years). Causative organisms included fungi, Staphylococcus aureus (3 cases each), Corynebacterium sp. (2 cases), Streptococcus viridans, VRE, Brucella sp., Clostridium sp., Nocardia sp. and Erysipelothrix sp. (one case each). Skin manifestations of endocarditis and/or splenomegaly were not reported in these patients. Septic emboli and mycotic aneurysms were relatively common. The overall mortality rate was 50% (7 of 14 patients died). Infective endocarditis seems to be rare in renal transplant recipients. The few reported cases are characterized by unusual causative micro-organisms and atypical clinical presentation. Further studies are needed to delineate the magnitude and scope of this association.

Topics: Adult; Brucella melitensis; Brucellosis; Ceftriaxone; Cephalosporins; Doxycycline; Drug Therapy, Combination; Endocarditis, Bacterial; Erysipelothrix; Erysipelothrix Infections; Female; Humans; Kidney Transplantation; Male; MEDLINE; Postoperative Complications; Rifampin

Topics: Aged, 80 and over; Amoxicillin; Arthroplasty, Replacement, Knee; Ceftriaxone; Chemical and Drug Induced Liver Injury; Drug Substitution; Erysipelothrix; Erysipelothrix Infections; Humans; Knee Prosthesis; Levofloxacin; Male; Prosthesis-Related Infections; Recurrence; Reoperation; Sepsis

Erysipelothrix rhusiopathiae is a gram-positive bacillus which is found worldwide. Although bloodstream infections caused by E. rhusiopathiae are not common, there is a strong association between bacteremia and the development of infective endocarditis. The risk of human infection with Erysipelothrix is closely related to the opportunity for exposure to the organisms. We report a case of community-acquired meningitis as an initial manifestation of E. rhusiopathiae endocarditis in a 56-year-old woman, who had no history of exposure to animals.

Topics: Acute Disease; Aged; Anti-Bacterial Agents; Ceftriaxone; Endocarditis, Bacterial; Erysipelothrix; Erysipelothrix Infections; Female; Humans; Male; Meningitis, Bacterial; Middle Aged

The bacterial species Erysipelothrix rhusiopathiae is found worldwide as a commensal or a pathogen in a variety of animals. One well-defined pattern of human infection is an uncommon bacteremic form, with or without cutaneous involvement, usually complicated by endocarditis. We report the case of a 38-year-old male butcher with E. rhusiopathiae bacteremia, native aortic valve endocarditis and perivalvular abscess. The patient was released after six weeks of intravenous ceftriaxone and aortic valve replacement because of severe regurgitation.

Topics: Abscess; Adult; Aortic Valve; Aortic Valve Insufficiency; Bacteremia; Ceftriaxone; Cephalosporins; Endocarditis, Bacterial; Erysipelothrix Infections; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Male