ro13-9904 and Arthritis--Rheumatoid

Salmonella ovarian abscess in a patient with rheumatoid arthritis (RA) is reported here. A 33-year-old nulliparous woman with a 16-year history of RA who had been treated with corticosteroid and immunosuppressive drugs was diagnosed as having a non-typhoidal Salmonella ovarian abscess which might have been preceded by an occurrence of endometriotic cyst. Multidisciplinary therapy including surgical intervention was required to complete the eradication of infection. Although Salmonella ovarian abscess is rare, it may cause a serious complication in the ovary harboring endometriotic cyst through sustained presence of Salmonella bacteraemia.

Topics: Abscess; Adult; Anti-Bacterial Agents; Arthritis, Rheumatoid; Ceftriaxone; Female; Humans; Lincomycin; Ovarian Diseases; Salmonella enteritidis; Salmonella Infections

Topics: Adenocarcinoma; Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Ceftriaxone; Colonic Neoplasms; Diabetes Mellitus, Type 2; Female; Gram-Negative Bacterial Infections; Hip Joint; Humans; Immunocompromised Host; Immunosuppressive Agents; Paracoccus; Ribotyping; RNA, Bacterial; RNA, Ribosomal, 16S; Synovial Fluid

Topics: Anti-Bacterial Agents; Arthritis, Rheumatoid; Atrial Flutter; Ceftriaxone; Diagnosis, Differential; Echocardiography; Electric Countershock; Electrocardiography; Humans; Male; Middle Aged; Pericardiectomy; Pericarditis; Treatment Outcome; Whipple Disease

Topics: Aged; Ampicillin; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Ceftriaxone; Drug Eruptions; Drug Therapy, Combination; Eosinophilia; Female; Humans; Methylprednisolone; Sulbactam; Sulfasalazine; Syndrome

Topics: Amoxicillin; Anti-Bacterial Agents; Arthritis, Rheumatoid; Ceftriaxone; Drug Combinations; Female; Fever of Unknown Origin; Glucosamine; Humans; Meningitis, Aseptic; Middle Aged; Sulfasalazine; Treatment Outcome; Withholding Treatment

Topics: Aged; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bacteremia; Bronchopneumonia; Ceftriaxone; Debridement; Dermatitis, Perioral; Diagnosis, Differential; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Emphysema; Fasciitis, Necrotizing; Fatal Outcome; Female; Heart Failure; Humans; Metronidazole; Respiration, Artificial; Streptococcus agalactiae; Vancomycin

Fifteen patients with acute exacerbation of rheumatoid arthritis each received a 1 g bolus intravenous injection of ceftriaxone. Serum and synovial fluid was sampled at intervals between 1 h and 24 h later and assayed for ceftriaxone. Synovial fluid leucocyte counts and albumin content were measured concomitantly. Detectable levels of ceftriaxone were found in synovial fluid and serum 24 h after injection. Synovial fluid ceftriaxone concentration ranged between 66% and 100% of the concomitant serum levels. No correlation was observed between synovial fluid ceftriaxone concentration and synovial fluid leucocyte count and albumin concentration.

Topics: Arthritis, Rheumatoid; Ceftriaxone; Humans; Kinetics; Leukocyte Count; Serum Albumin; Synovial Fluid