ro13-9904 and Aortic-Aneurysm

Infections of major vessels leading to mycotic aneurysms can be a diagnostic dilemma for clinicians, and can be accompanied by a high mortality rate. Successful treatment of this condition often requires a high index of suspicion and prompt medical and surgical attention. The authors report two cases of infectious aortitis caused by pneumococcus that evolved during hospitalization, and discuss diagnostic difficulties that accompany this entity.

Topics: Aged; Anti-Bacterial Agents; Aortic Aneurysm; Aortitis; Ceftriaxone; Female; Humans; Male; Middle Aged; Pneumococcal Infections

Mycotic aneurysms of the ascending aorta are rare. We report the case of a 38-year-old woman with systemic lupus erythematosus being treated with steroids who presented with a large Neisseria gonorrhoeae ascending aortic aneurysm. She was successfully treated with surgical resection of the aneurysm and prolonged postoperative antibiotic therapy.

Topics: Adult; Aneurysm, Infected; Aortic Aneurysm; Ceftriaxone; Combined Modality Therapy; Drug Therapy, Combination; Female; Gentamicins; Gonorrhea; Humans; Vancomycin

Seven patients with abdominal aortic aneurysms infected with salmonella organisms were surgically treated between 1985 and 1988. Salmonella culture was obtained from the wall of the aneurysm in every patient, and in five patients it was identified as Salmonella typhimurium. S. choleraesuis and salmonella group D (isolated from this patient but not speciated) were found in the other two remaining patients. Three patients underwent aneurysmal resection with axillofemoral bypass grafting, and three patients were treated by aneurysmal resection with in situ graft; two of this group had the wall and infective periaortic tissue excised. One patient died during the operation as a result of rupture of the aneurysm. Therapeutic doses of antibiotic drugs were given to all of the patients. Although two of the patients in the first group (with the axillofemoral bypass graft) died and the remaining patient had very complicated postoperative course, all the patients in the second group (with in situ graft) survived. We think that in situ graft placement after an extensive debridement of the aneurysmal wall and infected periaortic tissue together with more effective and adequate antibiotic therapy for at least 6 weeks after the operation is a satisfactory method of surgical treatment of this condition. However, graft infection is still a possibility, therefore regular follow-up is needed.

Topics: Aged; Ampicillin; Aorta, Abdominal; Aortic Aneurysm; Ceftriaxone; Female; Humans; Male; Middle Aged; Salmonella Infections; Salmonella typhimurium