ro13-9904 and Anti-Glomerular-Basement-Membrane-Disease

A 90-year-old woman who had bloody diarrhoea, nausea, weakness and reduced urine output was found to have acute kidney injury. Her inflammatory markers were raised and her chest X-ray suggested an inflammatory process. She was initially suspected to have acute kidney injury secondary to dehydration and sepsis but when her autoimmune screen returned positive for antiglomerular basement membrane antibodies our diagnosis and management strategy was reconsidered. This is a case report of Goodpasture disease presenting in an elderly patient.

Topics: Acute Kidney Injury; Aged, 80 and over; Albuterol; Anti-Bacterial Agents; Anti-Glomerular Basement Membrane Disease; Bronchodilator Agents; Ceftriaxone; Diarrhea; Esomeprazole; Fatal Outcome; Female; Humans; Nausea; Palliative Care; Patient Comfort; Plasma Exchange; Proton Pump Inhibitors

We describe a female patient with Alport disease who developed antiglomerular basement membrane nephritis late after kidney transplantation during the treatment of an acute bacterial pyelonephritis and discuss the potential role of the infection as a trigger for the development of this nephritis.

Topics: Adolescent; Anti-Bacterial Agents; Anti-Glomerular Basement Membrane Disease; Autoantibodies; Basement Membrane; Ceftriaxone; Drug Substitution; Escherichia coli Infections; Female; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Glomerulus; Kidney Transplantation; Nephritis, Hereditary; Plasmapheresis; Pulse Therapy, Drug; Pyelonephritis; Treatment Outcome