ro13-9904 and Anemia--Aplastic

Clinical efficacy of 3rd generation cephalosporins i.e. oral cefpodoxime and parenteral ceftriaxone was studied in the treatment of children with oncohematologic pathology. Cefpodoxime proved to be efficient in cases of moderate infectious complications in regard to the respiratory tracts. The oral administration of the drug provided its usage in outpatients. Ceftriaxone had a favourable effect in the treatment of children with more severe processes as a rule at the background of agranulocytosis and a lower immune response often with a tendency to generalization. No side effects of the cephalosporins were observed.

Topics: Administration, Oral; Agranulocytosis; Anemia, Aplastic; Cefpodoxime; Ceftizoxime; Ceftriaxone; Cephalosporins; Child; Child, Preschool; Hematologic Neoplasms; Humans; Injections, Intraperitoneal; Opportunistic Infections; Respiratory Tract Infections; Treatment Outcome

Topics: Aged, 80 and over; Anemia, Aplastic; Anti-Bacterial Agents; Bone Marrow; Ceftriaxone; Coinfection; Dermatitis, Exfoliative; Escherichia coli; Escherichia coli Infections; Humans; Injections, Intravenous; Male; Photosensitivity Disorders; Skin; Staphylococcal Skin Infections; Staphylococcus aureus

A newborn baby, with transient pancytopenia concurrent to Echovirus type 11 infection, was hospitalized for fever, diarrhea, rash, generalized petechiae and hepatosplenomegaly. Subsequent investigation showed bone marrow failure. To our knowledge this is the first reported case of bone marrow failure with concomitant enteroviral infection.

Topics: Anemia, Aplastic; Ceftriaxone; Cephalosporins; Echovirus Infections; Enterovirus B, Human; Humans; Immunoglobulins, Intravenous; Infant, Newborn; Male; Receptors, Virus