ro13-9904 and Adenocarcinoma

The primary fallopian tube invader adenocarcinoma is a preoperative diagnosis rarely reported in the literature, because is the most uncommon of all gynecological tumors, with prevalence from 0.3 to 1.8%. Since its clinical evolution is very unspecific, in general this tumor is diagnosed during a laparothomy for other purpose or by the pathologist in the final histopathological report. The most frequent signs and symptoms are abdominal pain or a pelvic mass in 80% of cases; transvaginal bleeding in 50%, intense transvaginal serohematic discharge (hidrops tubae profluens) in 11.1%, and peritonitis in pelvis in 3.7%. In 25 to 60% of the cases a report of adenocarcinoma in the pap smear with negative endometrial biopsy can be found. The treatment is predominantly surgical, as that of epithelial ovarian carcinoma, and consists of an intraperitoneal washing, total abdominal hysterectomy with bilateral salpingo-oophorectomy and a proper staging. It is required an omentectomy with pelvic and paraaortic lymphadenectomy in systematic way. In the more advanced stages III and IV that required a radical debulking, we have to be very emphatic in citoreduction. In some cases, as the persistence or recurrence of illness, it can be necessary adjuvant chemotherapy. In some patients in early stage I or II with low risk, the complete staging could not be necessary. There is controversy about administration criteria of adjuvant treatment, since there is not evidence of survival increase related to its use. The five years survival rate was 64% for stage I, 42% for stage II, 32% for stage III, and 17% for stage IV. Fallopian tube malignancies are rare and involve a poor prognosis.

Topics: Abdomen, Acute; Acute Kidney Injury; Adenocarcinoma; Anti-Bacterial Agents; Anuria; Ceftriaxone; Clindamycin; Fallopian Tube Neoplasms; Female; Humans; Hysterectomy; Middle Aged; Ovariectomy; Pelvic Inflammatory Disease; Peritonitis

Topics: Adenocarcinoma; Aged; Anti-Bacterial Agents; Bacteremia; Cefazolin; Ceftriaxone; Colectomy; Colorectal Neoplasms; Combined Modality Therapy; Female; Humans; Streptococcal Infections; Streptococcus gallolyticus

Topics: Adenocarcinoma; Amoxicillin-Potassium Clavulanate Combination; Bacteria, Anaerobic; Ceftriaxone; Combined Modality Therapy; Drainage; Drug Resistance, Microbial; Fever; Firmicutes; Gram-Positive Bacterial Infections; Gram-Positive Cocci; Humans; Lymph Node Excision; Lymphocele; Male; Middle Aged; Postoperative Complications; Prostatectomy; Prostatic Neoplasms

Topics: Adenocarcinoma; Adrenal Cortex Hormones; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Arthritis, Infectious; Arthritis, Rheumatoid; Ceftriaxone; Colonic Neoplasms; Diabetes Mellitus, Type 2; Female; Gram-Negative Bacterial Infections; Hip Joint; Humans; Immunocompromised Host; Immunosuppressive Agents; Paracoccus; Ribotyping; RNA, Bacterial; RNA, Ribosomal, 16S; Synovial Fluid

Topics: Adenocarcinoma; Amikacin; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Ceftriaxone; Chemotherapy, Adjuvant; Colostomy; Diabetes Mellitus, Type 1; Disease Susceptibility; Drug Therapy, Combination; Gardnerella vaginalis; Gram-Positive Bacterial Infections; Humans; Male; Metronidazole; Middle Aged; Peritoneal Neoplasms; Sigmoid Neoplasms

A 62-year-old man with adenocarcinoma underwent complete resection with a right upper lobectomy and en-bloc resection of the chest wall, with metallic clips applied to the vertebral nerve roots. A sudden deterioration in neurological status occurred due to pneumocephalus and ascending bacterial meningitis resulting from a subarachnoid-pleural fistula. The neurological status normalized after thoracoplasty and ceftriaxone treatment.

Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anti-Bacterial Agents; Brain Diseases; Ceftriaxone; Fistula; Humans; Iatrogenic Disease; Lung Neoplasms; Male; Meningitis, Pneumococcal; Middle Aged; Pleural Diseases; Pneumocephalus; Pneumonectomy; Reoperation; Respiratory Tract Fistula; Streptococcus pneumoniae; Subarachnoid Space; Thoracoplasty; Tomography, X-Ray Computed; Treatment Outcome

The Lyme disease spirochete, Borrelia burgdorferi, can be recovered long after initial infection, even from antibiotic-treated patients, indicating that it resists eradication by host defense mechanisms and antibiotics. Since B. burgdorferi first infects skin, the possible protective effect of skin fibroblasts from an antibiotic commonly used to treat Lyme disease, ceftriaxone, was examined. Human foreskin fibroblasts protected B. burgdorferi from the lethal action of a 2-day exposure to ceftriaxone at 1 microgram/mL, 10-20 x MBC. In the absence of fibroblasts, organisms did not survive. Spirochetes were not protected from ceftriaxone by glutaraldehyde-fixed fibroblasts or fibroblast lysate, suggesting that a living cell was required. The ability of the organism to survive in the presence of fibroblasts was not related to its infectivity. Fibroblasts protected B. burgdorferi for at least 14 days of exposure to ceftriaxone. Mouse keratinocytes, HEp-2 cells, and Vero cells but not Caco-2 cells showed the same protective effect. Thus, several eukaryotic cell types provide the Lyme disease spirochete with a protective environment contributing to its long-term survival.

Topics: Adenocarcinoma; Animals; Borrelia burgdorferi; Borrelia burgdorferi Group; Carcinoma, Squamous Cell; Ceftriaxone; Cell Survival; Cells, Cultured; Colonic Neoplasms; Culture Media; Fibroblasts; Humans; Laryngeal Neoplasms; Mice; Tumor Cells, Cultured; Vero Cells