ro13-9904 and Actinomycetales-Infections

Topics: Actinomycetales Infections; Anti-Bacterial Agents; Aortic Valve Stenosis; Bacteremia; Brevibacterium; Ceftriaxone; Disease Susceptibility; Drug Therapy, Combination; Emergencies; Endocarditis, Bacterial; Facial Dermatoses; Gentamicins; Humans; Levofloxacin; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Recurrence; Tetracycline; Vancomycin; Wound Infection

Topics: Actinomycetales Infections; Adult; Anti-Bacterial Agents; Ceftriaxone; Cholecystectomy; Endocarditis, Bacterial; Humans; Male; Micrococcaceae; Mitral Valve Prolapse; Postoperative Complications; Treatment Outcome

Topics: Actinomycetales Infections; Ceftriaxone; Diagnosis, Differential; Doxycycline; Exudates and Transudates; Female; HIV Infections; Humans; Male; Pleural Effusion; Rhodococcus equi; Tomography, X-Ray Computed; Treatment Outcome

Two uncommon presentations of Arcanobacterium Haemolyticum infection (sinusitis and pharyngitis) are described, emphasizing the poor response to commonly used antibiotics and the possibility of serious local and systemic complications. The difficulties still encountered in the clinical diagnosis are underlined, since this organism could easily pass unrecognized in bacteriological cultures.

Topics: Actinomycetales; Actinomycetales Infections; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Betamethasone; Ceftriaxone; Cerebrospinal Fluid Rhinorrhea; Female; Humans; Injections, Intramuscular; Male; Tomography, X-Ray Computed

A 67-year-old man presented with myalgia, muscle atrophy, and a history of seronegative polyarthritis. Blood tests showed inflammation but no hematologic or immunologic abnormalities. Muscle biopsy revealed no vasculitis or myositis but Tropheryma whipplei was detected by polymerase chain reaction in muscle, blood, and duodenum specimens; this was confirmed by immunohistochemistry. Ceftriaxone led to clinical improvement. Although rare, Whipple's disease should be considered in the differential diagnosis of diffuse myopathy.

Topics: Actinomycetales; Actinomycetales Infections; Aged; Anti-Bacterial Agents; Ceftriaxone; Diagnosis, Differential; DNA, Bacterial; Humans; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Muscular Disorders, Atrophic; Treatment Outcome; Whipple Disease

Corynebacteria are more commonly being recognized as significant human pathogens. We describe a case of Coryneform group A-4 sepsis secondary to infection of a Hickman catheter in an immunocompromised man; the organism was identified by biochemical analysis conducted at the Louisiana State Reference Laboratory.

Topics: Actinomycetales; Actinomycetales Infections; Bacteremia; Catheters, Indwelling; Ceftriaxone; Cephalosporins; Humans; Immunocompromised Host; Male; Middle Aged; Sepsis