ro-60-0175 and Gambling

Adding reward-concurrent cues to a rat gambling task (rGT) increases risky choice. This cued version of the task may reflect an "addiction-like" cognitive process, more similar to human gambling than the uncued task. Serotonergic drugs that target 5-HT. The aim of this study was to determine the effects of SB 242,084 and M100907, selective antagonists at the 5-HT. SB 242,084 significantly and dose-dependently increased choice of the most optimal option in the cued rGT only, despite concurrently increasing impulsive responses made prematurely on both the cued and uncued rGT. M100907 and Ro-60-0175 did not alter risky decision making, but nevertheless produced the expected decrease in premature responses on both task variants.. These findings demonstrate that the 5-HT

Topics: Acoustic Stimulation; Animals; Conditioning, Operant; Cues; Decision Making; Dose-Response Relationship, Drug; Ethylamines; Gambling; Indoles; Male; Photic Stimulation; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT2C; Reward; Serotonin 5-HT2 Receptor Antagonists