ro 5-4864 has been researched along with Seizures in 24 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two compounds with high affinity for the "peripheral type" benzodiazepine binding sites, PK 11195 (an isoquinoline derivative) and RO5-4864 (a benzodiazepine derivative) can modify the sensitivity of DBA/2J mice to audiogenic seizures." | 7.67 | Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice. ( Allam, DE; Bénavidès, J; Dubroeucq, MC; Guérémy, C; Guilloux, F; Le Fur, G; Mizoule, J; Renault, C; Uzan, A, 1984) |
| "Anticonvulsant actions of the nootropic drug nefiracetam were studied using EL mice, an animal model of epilepsy, in which peripheral-type benzodiazepine receptors (PBRs) might be involved in their epileptogenesis." | 3.70 | Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. ( Nabeshima, T; Nakamoto, Y; Shiotani, T; Watabe, S; Yoshii, M, 2000) |
| " PK 11195 (up to 120 mg kg-1) was ineffective at counteracting seizures caused by the convulsant benzodiazepine Ro 5-3663, although this dose did increase the latency to seize after injection with pentylenetetrazole." | 3.67 | Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance. ( File, SE, 1984) |
| " Muscimol potently inhibited the seizures and reversed increases in cell firing elicited by Ro 5-4864." | 3.67 | Electrophysiological and pharmacological actions of the convulsant benzodiazepine Ro 5-4864. ( Cott, J; Hommer, D; Paul, S; Skolnick, P; Weissman, BA, 1984) |
| "Two compounds with high affinity for the "peripheral type" benzodiazepine binding sites, PK 11195 (an isoquinoline derivative) and RO5-4864 (a benzodiazepine derivative) can modify the sensitivity of DBA/2J mice to audiogenic seizures." | 3.67 | Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice. ( Allam, DE; Bénavidès, J; Dubroeucq, MC; Guérémy, C; Guilloux, F; Le Fur, G; Mizoule, J; Renault, C; Uzan, A, 1984) |
| "The effects of chemically and electrically-evoked seizures on [3H]nitrendipine binding to voltage-dependent calcium channels in mouse brain were determined 30 and 60 min following the initiation of convulsions." | 3.67 | The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain. ( Bolger, GT; Weissman, BA, 1987) |
| "The present study was designed to investigate whether D,L-laudanosine (a breakdown product of the neuromuscular relaxant atracurium besylate) interacts with benzodiazepinergic receptors or muscarinic receptors, both of which are involved in epilepsy and other types of seizures." | 3.67 | Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors. ( Gavish, M; Katz, Y, 1989) |
| "KA-induced seizure activity did not significantly alter both variables until PND 21." | 1.28 | Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain. ( Baudry, M; el-Skaf, G; Lynch, G; Najm, I; Tocco, G; Vanderklish, P, 1992) |
| "Myoclonus was the seizure type with the lowest threshold for all three agents." | 1.28 | Toxicokinetics of Ro 5-4864, lindane and picrotoxin compared. ( Drummer, HL; Woolley, DE, 1991) |
| "Both PTX and Ro 5-4864 produced myoclonic seizures, primarily between 15-40 min after administration; myoclonus was followed by more severe seizures after PTX." | 1.28 | Ro 5-4864, like picrotoxin, enhances EPSP-spike coupling in the freely behaving rat. ( Dai, KS; Woolley, DE, 1991) |
| "Ro 15-1788 antagonised the tonic convulsions triggered by the drug combinations when it was given at the same time as Ro 5-4864; this antagonism was not observed when the drugs were injected at different times." | 1.27 | On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain. ( File, SE; Green, AR; Nutt, DJ; Vincent, ND, 1984) |
| "RO5-4864-induced convulsions were blocked by diazepam, clonazepam, pentobarbital, ethanol and amino-oxyacetic acid (AOAA)." | 1.27 | A possible role of a GABAergic mechanism in the convulsant action of RO5-4864. ( Rastogi, SK; Ticku, MK, 1985) |
| "Both the peak of tonic seizure susceptibility (21 days) and the time course of its subsequent age-dependent decline closely paralleled the change in audiogenic seizure susceptibility in the DBA/2 strain." | 1.27 | Ontogeny of susceptibility to the convulsant, Ro 5-4864, and its relationship to audiogenic seizure susceptibility in inbred mice. ( Roderick, TH; Seale, TW; Skolnick, P, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (66.67) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| File, SE | 3 |
| Niznik, HB | 2 |
| Burnham, WM | 2 |
| Kish, SJ | 2 |
| Pellow, S | 1 |
| Okazaki, MM | 1 |
| Weissman, BA | 3 |
| Cott, J | 1 |
| Hommer, D | 1 |
| Paul, S | 1 |
| Skolnick, P | 3 |
| Green, AR | 1 |
| Nutt, DJ | 1 |
| Vincent, ND | 1 |
| Bénavidès, J | 1 |
| Guilloux, F | 1 |
| Allam, DE | 1 |
| Uzan, A | 1 |
| Mizoule, J | 1 |
| Renault, C | 1 |
| Dubroeucq, MC | 1 |
| Guérémy, C | 1 |
| Le Fur, G | 1 |
| Byrnes, JJ | 1 |
| Miller, LG | 1 |
| Perkins, K | 1 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
| Yoshii, M | 2 |
| Nakamoto, Y | 2 |
| Watabe, S | 2 |
| Mugishima, G | 1 |
| Habu, H | 1 |
| Shiotani, T | 2 |
| Nabeshima, T | 2 |
| Najm, I | 1 |
| el-Skaf, G | 1 |
| Tocco, G | 1 |
| Vanderklish, P | 1 |
| Lynch, G | 1 |
| Baudry, M | 1 |
| Kokka, N | 1 |
| Sapp, DW | 1 |
| Witte, U | 1 |
| Olsen, RW | 1 |
| Drummer, HL | 2 |
| Woolley, DE | 3 |
| Dai, KS | 2 |
| Hasan, ZA | 1 |
| Bolger, GT | 1 |
| Katz, Y | 1 |
| Gavish, M | 1 |
| Kunchandy, J | 2 |
| Kulkarni, SK | 2 |
| Basile, AS | 1 |
| Rastogi, SK | 1 |
| Ticku, MK | 1 |
| Massotti, M | 1 |
| Lucantoni, D | 1 |
| Valin, A | 1 |
| Bryere, P | 1 |
| Naquet, R | 1 |
| Seale, TW | 1 |
| Roderick, TH | 1 |
1 review available for ro 5-4864 and Seizures
| Article | Year |
|---|---|
[Mitochondrial benzodiazepine receptors (MBR) in association with neurological disorders].
Topics: Animals; Benzodiazepinones; Convulsants; Mice; Mice, Mutant Strains; Mitochondria; Receptors, GABA-A | 1998 |
23 other studies available for ro 5-4864 and Seizures
| Article | Year |
|---|---|
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Diazepam; Drug Interactions; Drug Toleranc | 1984 |
Benzodiazepine receptor binding following amygdala-kindled convulsions: differing results in washed and unwashed brain membranes.
Topics: Amygdala; Animals; Benzodiazepinones; Brain; Buffers; Cell Membrane; Cerebral Cortex; Flunitrazepam; | 1984 |
Characteristics of an atypical benzodiazepine, Ro 5-4864.
Topics: Animals; Arousal; Behavior, Animal; Benzodiazepinones; Brain; Convulsants; Drug Interactions; Rats; | 1984 |
Binding of [3H]flunitrazepam and [3H]Ro5-4864 to crude homogenates of amygdala-kindled rat brain: two months post-seizure.
Topics: Amygdala; Animals; Benzodiazepinones; Brain; Flunitrazepam; Kindling, Neurologic; Kinetics; Male; Mu | 1983 |
Electrophysiological and pharmacological actions of the convulsant benzodiazepine Ro 5-4864.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Electrophysiology; Male; Muscimol; Ra | 1984 |
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Diazepam; Electroshock; Flumazenil; M | 1984 |
Opposite effects of an agonist, RO5-4864, and an antagonist, PK 11195, of the peripheral type benzodiazepine binding sites on audiogenic seizures in DBA/2J mice.
Topics: Acoustic Stimulation; Animals; Benzodiazepinones; Convulsants; Dose-Response Relationship, Drug; Iso | 1984 |
Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; GABA-A R | 1993 |
Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Disease Models, Animal; Epilepsy; Male; Mi | 2000 |
Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain.
Topics: Animals; Benzodiazepinones; Biogenic Polyamines; Brain; Brain Chemistry; Cerebral Cortex; Electropho | 1992 |
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds | 1992 |
Toxicokinetics of Ro 5-4864, lindane and picrotoxin compared.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Body Temperature; Body Weight; Convulsants; Dose-Respo | 1991 |
Changes in limbic evoked potentials produced by the atypical benzodiazepine Ro 5-4864.
Topics: Animals; Benzodiazepinones; Convulsants; Evoked Potentials; Female; Hexachlorocyclohexane; Hippocamp | 1991 |
Ro 5-4864, like picrotoxin, enhances EPSP-spike coupling in the freely behaving rat.
Topics: Animals; Benzodiazepinones; Convulsants; Electric Stimulation; Evoked Potentials; Female; Hippocampu | 1991 |
The effects of chemically and electrically-induced convulsions on [3H]nitrendipine binding in mouse brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors.
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Flunitrazepam; Isoquinolines; Kidney; Quinuclidinyl Ben | 1989 |
Modulatory effect of alpha 2 adrenoceptor agonists on Ro 5-4864-induced convulsions in rats and mice.
Topics: Animals; Anticonvulsants; Azepines; Benzodiazepinones; Brain; Clonidine; Convulsants; Guanfacine; Gu | 1987 |
Maximal electroshock increases the density of [3H]Ro 5-4864 binding to mouse cerebral cortex.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Binding, Competitive; Brain; Cerebral Cortex; Convulsan | 1987 |
On the convulsant action of DMCM and Ro 5-4864 in mice.
Topics: Adrenergic alpha-Agonists; Animals; Benzodiazepinones; Carbolines; Convulsants; Female; Male; Mice; | 1988 |
A possible role of a GABAergic mechanism in the convulsant action of RO5-4864.
Topics: Animals; Benzodiazepinones; Bicuculline; Convulsants; Dose-Response Relationship, Drug; GABA Antagon | 1985 |
The peripheral benzodiazepine receptor ligand Ro 5-4864 induces supraspinal convulsions in rabbits. Reversal by the central benzodiazepine antagonist Ro 15-1788.
Topics: Animals; Benzodiazepinones; Convulsants; Electrodes, Implanted; Electroencephalography; Flumazenil; | 1986 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; | 1986 |
Ontogeny of susceptibility to the convulsant, Ro 5-4864, and its relationship to audiogenic seizure susceptibility in inbred mice.
Topics: Acoustic Stimulation; Age Factors; Animals; Benzodiazepinones; Convulsants; Dose-Response Relationsh | 1987 |