ro 5-4864 has been researched along with Neuroblastoma in 3 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we have shown that micromolar concentrations of FGIN-1-27 and Ro 5-4864, two chemically unrelated PBR ligands are toxic for both PBR-expressing SK-N-BE neuroblastoma cells and PBR-deficient Jurkat lymphoma cells." | 3.73 | Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression. ( Belachew, S; Hans, G; Lallemend, F; Malgrange, B; Moonen, G; Nguyen, L; Rigo, JM; Robe, P; Rogister, B; Wislet-Gendebien, S, 2005) |
| "The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture." | 3.67 | Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. ( Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hans, G | 1 |
| Wislet-Gendebien, S | 1 |
| Lallemend, F | 1 |
| Robe, P | 1 |
| Rogister, B | 1 |
| Belachew, S | 1 |
| Nguyen, L | 1 |
| Malgrange, B | 1 |
| Moonen, G | 1 |
| Rigo, JM | 1 |
| Kragie, L | 1 |
| Doyle, D | 1 |
| Gorman, AM | 1 |
| O'Beirne, GB | 1 |
| Regan, CM | 1 |
| Williams, DC | 1 |
3 other studies available for ro 5-4864 and Neuroblastoma
| Article | Year |
|---|---|
Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression.
Topics: Apoptosis; Benzodiazepinones; Cell Survival; Humans; Indoleacetic Acids; Jurkat Cells; Ligands; Memb | 2005 |
Benzodiazepines inhibit temperature-dependent L-[125I]triiodothyronine accumulation into human liver, human neuroblast, and rat pituitary cell lines.
Topics: Adenoma; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Cell Line; Convulsants; D | 1992 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma | 1989 |