ro 5-4864 has been researched along with Glioma in 15 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM." | 7.69 | Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. ( Basile, AS; Friedman, HS; Gallo, JM; Higgins, PE; Kupczyk-Subotkowska, L; Siahaan, TJ; Song, D, 1997) |
| "An experimental model to study synthesis of cholesterol and pregnenolone from the precursor mevalonolactone (MVA) was developed in C6-2B glioma cells." | 7.68 | Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam. ( Costa, E; Guarneri, P; Pan, B; Papadopoulos, V, 1992) |
| " In the present work, we investigated the ability of the specific PBR ligands, PK 11195 or Ro5-4864, to affect mitochondrial potential and to induce apoptotic cell death in rat C6 glioma cells." | 3.72 | Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. ( Abbracchio, MP; Ceruti, S; Chelli, B; Costa, B; Da Pozzo, E; Gremigni, V; Lena, A; Martini, C; Rossi, L; Salvetti, A; Scatena, F; Vanacore, R, 2004) |
| " On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM." | 3.69 | Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. ( Basile, AS; Friedman, HS; Gallo, JM; Higgins, PE; Kupczyk-Subotkowska, L; Siahaan, TJ; Song, D, 1997) |
| "An experimental model to study synthesis of cholesterol and pregnenolone from the precursor mevalonolactone (MVA) was developed in C6-2B glioma cells." | 3.68 | Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam. ( Costa, E; Guarneri, P; Pan, B; Papadopoulos, V, 1992) |
| " To elucidate the biological role of the PBD receptor on mitochondria, we examined the effect of PBDs on mitochondrial morphology in C6 and T98G glioma cells using rhodamine 123 and quantitative electron microscopy." | 3.68 | Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells. ( Becker, DP; Black, KL; Ikezaki, K; Shiraishi, T, 1991) |
| "The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture." | 3.67 | Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. ( Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC, 1989) |
| "The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay." | 3.67 | Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. ( Kunert-Radek, J; Pawlikowski, M; Radek, A; Stepien, H, 1988) |
| "Binding of the isoquinoline PK 11195 and of the benzodiazepines Ro5-4864 and flunitrazepam was compared in glioma cells and tissues." | 3.67 | Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. ( Junck, L; Mancini, WR; Olson, JM; Penney, JB; Young, AB, 1988) |
| "Although gliomas have a high density of the peripheral-type benzodiazepine binding site, PET scans with a selective ligand for this site, [11C] Ro5-4864, failed to demonstrate higher radioactivity levels in human gliomas than in brain." | 1.28 | PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site. ( Ciliax, BJ; Jewett, DM; Junck, L; Kilbourn, MR; Koeppe, RA; McKeever, PE; Olson, JM; Starosta-Rubinstein, S; Watkins, GL; Wieland, DM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Dort, ME | 1 |
| Ciliax, BJ | 2 |
| Gildersleeve, DL | 1 |
| Sherman, PS | 1 |
| Rosenspire, KC | 1 |
| Young, AB | 2 |
| Junck, L | 3 |
| Wieland, DM | 2 |
| Kupczyk-Subotkowska, L | 1 |
| Siahaan, TJ | 1 |
| Basile, AS | 1 |
| Friedman, HS | 1 |
| Higgins, PE | 1 |
| Song, D | 1 |
| Gallo, JM | 1 |
| Mohler, ML | 1 |
| Kang, GS | 1 |
| Hong, SS | 1 |
| Patil, R | 1 |
| Kirichenko, OV | 1 |
| Li, W | 1 |
| Rakov, IM | 1 |
| Geisert, EE | 1 |
| Miller, DD | 1 |
| Chelli, B | 1 |
| Lena, A | 1 |
| Vanacore, R | 1 |
| Da Pozzo, E | 1 |
| Costa, B | 2 |
| Rossi, L | 1 |
| Salvetti, A | 1 |
| Scatena, F | 1 |
| Ceruti, S | 1 |
| Abbracchio, MP | 1 |
| Gremigni, V | 1 |
| Martini, C | 2 |
| Zlobina, GP | 1 |
| Kondakova, LI | 1 |
| Khalansky, AS | 1 |
| Selleri, S | 1 |
| Bruni, F | 1 |
| Costagli, C | 1 |
| Costanzo, A | 1 |
| Guerrini, G | 1 |
| Ciciani, G | 1 |
| Guarneri, P | 1 |
| Papadopoulos, V | 1 |
| Pan, B | 1 |
| Costa, E | 1 |
| Shiraishi, T | 1 |
| Black, KL | 2 |
| Ikezaki, K | 2 |
| Becker, DP | 1 |
| Broaddus, WC | 1 |
| Bennett, JP | 1 |
| Gorman, AM | 1 |
| O'Beirne, GB | 1 |
| Regan, CM | 1 |
| Williams, DC | 1 |
| Olson, JM | 2 |
| Koeppe, RA | 1 |
| Watkins, GL | 1 |
| Jewett, DM | 1 |
| McKeever, PE | 1 |
| Kilbourn, MR | 1 |
| Starosta-Rubinstein, S | 1 |
| Bergström, M | 1 |
| Mosskin, M | 1 |
| Ericson, K | 1 |
| Ehrin, E | 1 |
| Thorell, JO | 1 |
| von Holst, H | 1 |
| Norén, G | 1 |
| Persson, A | 1 |
| Halldin, C | 1 |
| Stone-Elander, S | 1 |
| Pawlikowski, M | 1 |
| Kunert-Radek, J | 1 |
| Radek, A | 1 |
| Stepien, H | 1 |
| Penney, JB | 1 |
| Mancini, WR | 1 |
15 other studies available for ro 5-4864 and Glioma
| Article | Year |
|---|---|
Radioiodinated benzodiazepines: agents for mapping glial tumors.
Topics: Animals; Autoradiography; Benzodiazepinones; Binding, Competitive; Glioma; Iodine Radioisotopes; Iso | 1988 |
Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzodiazepinones; Brain; Brain Neoplasms; Cell Death; D | 1997 |
Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues.
Topics: Animals; Antineoplastic Agents; Astrocytes; Biphenyl Compounds; Cell Line, Tumor; Cells, Cultured; D | 2006 |
Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodiazepinones; Caspase 3; Caspases; GABA-A Receptor A | 2004 |
Specific binding of [3H]diazepam in mouse glioblastoma: the influence of clonazepam and Ro 5-4864 on [3H]diazepam binding.
Topics: Animals; Benzodiazepinones; Binding Sites; Cell Line; Clonazepam; Diazepam; Glioma; Mice; Neuroglia | 1984 |
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.
Topics: Acetamides; Animals; Benzodiazepinones; Binding Sites; Cerebral Cortex; Clonazepam; Flumazenil; Glio | 2001 |
Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam.
Topics: Animals; Benzodiazepinones; Cholesterol; Diazepam Binding Inhibitor; Glioma; In Vitro Techniques; Lo | 1992 |
Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells.
Topics: Animals; Benzodiazepinones; Cell Line; Clonazepam; Culture Media, Serum-Free; Fluorescent Dyes; Glio | 1991 |
Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cell Division; Cell Line; DNA Replication; DNA, Neoplas | 1990 |
Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.
Topics: Affinity Labels; Benzodiazepinones; Binding, Competitive; Brain Neoplasms; Cerebral Cortex; Glioma; | 1990 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma | 1989 |
PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site.
Topics: Benzodiazepinones; Brain Neoplasms; Glioma; Humans; Receptors, GABA-A; Tomography, Emission-Computed | 1989 |
Peripheral benzodiazepine binding sites in human gliomas evaluated with positron emission tomography.
Topics: Benzodiazepinones; Brain Neoplasms; Carbon Radioisotopes; Glioma; Humans; Receptors, GABA-A; Tomogra | 1986 |
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
Topics: Astrocytoma; Benzodiazepines; Benzodiazepinones; Cell Division; Clonazepam; Diazepam; Female; Flumaz | 1988 |
Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging.
Topics: Benzodiazepines; Benzodiazepinones; Brain Neoplasms; Cells, Cultured; Flunitrazepam; Glioma; Humans; | 1988 |