ro 5-4864 has been researched along with Glioblastoma in 3 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "With the aid of the dye JC-1 and cyclosporin A, applied to glioblastoma cells, we now investigated the significance of opening of the mitochondrial permeability transition pore (MPTP) for ErPC3-induced apoptosis in interaction with the TSPO ligands, PK 11195 and Ro5 4864." | 3.74 | Ligands of the mitochondrial 18 kDa translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholine. ( Gavish, M; Kugler, W; Lakomek, M; Leschiner, S; Shandalov, Y; Spanier, I; Veenman, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cosimelli, B | 1 |
| Simorini, F | 1 |
| Taliani, S | 2 |
| La Motta, C | 1 |
| Da Settimo, F | 2 |
| Severi, E | 1 |
| Greco, G | 2 |
| Novellino, E | 2 |
| Costa, B | 2 |
| Da Pozzo, E | 2 |
| Bendinelli, S | 1 |
| Martini, C | 2 |
| Castellano, S | 1 |
| Viviano, M | 1 |
| Milite, C | 1 |
| Barresi, E | 1 |
| Bruno, A | 1 |
| Cosconati, S | 1 |
| Marinelli, L | 1 |
| Sbardella, G | 1 |
| Kugler, W | 1 |
| Veenman, L | 1 |
| Shandalov, Y | 1 |
| Leschiner, S | 1 |
| Spanier, I | 1 |
| Lakomek, M | 1 |
| Gavish, M | 1 |
3 other studies available for ro 5-4864 and Glioblastoma
| Article | Year |
|---|---|
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.
Topics: Amides; Cell Line, Tumor; Cyclization; Glioblastoma; Humans; Molecular Probes | 2011 |
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Computational Biol | 2014 |
Ligands of the mitochondrial 18 kDa translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholine.
Topics: Antineoplastic Agents; Apoptosis; Benzodiazepinones; Blotting, Western; Caspases; Cell Line, Tumor; | 2008 |