ro 5-4864 has been researched along with Epilepsy in 7 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anticonvulsant actions of the nootropic drug nefiracetam were studied using EL mice, an animal model of epilepsy, in which peripheral-type benzodiazepine receptors (PBRs) might be involved in their epileptogenesis." | 3.70 | Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. ( Nabeshima, T; Nakamoto, Y; Shiotani, T; Watabe, S; Yoshii, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakamoto, Y | 3 |
| Shiotani, T | 3 |
| Watabe, S | 3 |
| Nabeshima, T | 2 |
| Yoshii, M | 3 |
| Caldiroli, E | 1 |
| De Ponti, F | 1 |
| Cosentino, M | 1 |
| Marino, F | 1 |
| Fietta, AM | 1 |
| Taddei, M | 1 |
| Tartara, A | 1 |
| Zibetti, A | 1 |
| Mazzone, A | 1 |
| Lecchini, S | 1 |
| Frigo, GM | 1 |
| van Rijn, CM | 1 |
| Willems-van Bree, E | 1 |
| Rodrigues de Miranda, JF | 1 |
| Vossen, JM | 1 |
| Coenen, AM | 1 |
| Ducis, I | 1 |
| Norenberg, LO | 1 |
| Norenberg, MD | 1 |
| Brouillet, E | 1 |
| Chavoix, C | 1 |
| de la Sayette, V | 1 |
| Hantraye, P | 1 |
| Kunimoto, M | 1 |
| Khalili-Varasteh, M | 1 |
| Guibert, B | 1 |
| Fournier, D | 1 |
| Dodd, RH | 1 |
| Naquet, R | 1 |
7 other studies available for ro 5-4864 and Epilepsy
| Article | Year |
|---|---|
Nootropic nefiracetam inhibits proconvulsant action of peripheral-type benzodiazepines in epileptic mutant EL mice.
Topics: Animals; Benzodiazepinones; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Male; Mi | 2004 |
Peripheral-type benzodiazepine receptors in association with epileptic seizures in EL mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Binding Sites; Cell Fractionation; Convulsants; Epi | 1996 |
Carbamazepine affects neutrophil function through an action on peripheral benzodiazepine receptors.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Carbamazepine; Cells, Cultured; Chemotaxis, Leukocyte; C | 1997 |
Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Convulsants; Disease Models, Animal; Epilepsy; Male; Mi | 2000 |
Binding of Ro 5-4864 to brain membranes of rats with and without absence-like phenomena.
Topics: Animals; Benzodiazepinones; Brain Chemistry; Cell Membrane; Cerebellum; Convulsants; Epilepsy; Rats; | 1991 |
The benzodiazepine receptor in cultured astrocytes from genetically epilepsy-prone rats.
Topics: Animals; Animals, Newborn; Astrocytes; Benzodiazepinones; Cells, Cultured; Cerebral Cortex; Convulsa | 1990 |
Anticonvulsant activity of the diaryltriazine, LY81067: studies using electroencephalographic recording and positron emission tomography.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Brain; Convulsants; Electroencephalog | 1989 |