ro 5-4864 has been researched along with Brain Neoplasms in 6 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM." | 7.69 | Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. ( Basile, AS; Friedman, HS; Gallo, JM; Higgins, PE; Kupczyk-Subotkowska, L; Siahaan, TJ; Song, D, 1997) |
| " On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM." | 3.69 | Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. ( Basile, AS; Friedman, HS; Gallo, JM; Higgins, PE; Kupczyk-Subotkowska, L; Siahaan, TJ; Song, D, 1997) |
| "Binding of the isoquinoline PK 11195 and of the benzodiazepines Ro5-4864 and flunitrazepam was compared in glioma cells and tissues." | 3.67 | Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. ( Junck, L; Mancini, WR; Olson, JM; Penney, JB; Young, AB, 1988) |
| "Although gliomas have a high density of the peripheral-type benzodiazepine binding site, PET scans with a selective ligand for this site, [11C] Ro5-4864, failed to demonstrate higher radioactivity levels in human gliomas than in brain." | 1.28 | PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site. ( Ciliax, BJ; Jewett, DM; Junck, L; Kilbourn, MR; Koeppe, RA; McKeever, PE; Olson, JM; Starosta-Rubinstein, S; Watkins, GL; Wieland, DM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kupczyk-Subotkowska, L | 1 |
| Siahaan, TJ | 1 |
| Basile, AS | 1 |
| Friedman, HS | 1 |
| Higgins, PE | 1 |
| Song, D | 1 |
| Gallo, JM | 1 |
| Castellano, S | 1 |
| Taliani, S | 1 |
| Viviano, M | 1 |
| Milite, C | 1 |
| Da Pozzo, E | 1 |
| Costa, B | 1 |
| Barresi, E | 1 |
| Bruno, A | 1 |
| Cosconati, S | 1 |
| Marinelli, L | 1 |
| Greco, G | 1 |
| Novellino, E | 1 |
| Sbardella, G | 1 |
| Da Settimo, F | 1 |
| Martini, C | 1 |
| Broaddus, WC | 1 |
| Bennett, JP | 1 |
| Junck, L | 2 |
| Olson, JM | 2 |
| Ciliax, BJ | 1 |
| Koeppe, RA | 1 |
| Watkins, GL | 1 |
| Jewett, DM | 1 |
| McKeever, PE | 1 |
| Wieland, DM | 1 |
| Kilbourn, MR | 1 |
| Starosta-Rubinstein, S | 1 |
| Bergström, M | 1 |
| Mosskin, M | 1 |
| Ericson, K | 1 |
| Ehrin, E | 1 |
| Thorell, JO | 1 |
| von Holst, H | 1 |
| Norén, G | 1 |
| Persson, A | 1 |
| Halldin, C | 1 |
| Stone-Elander, S | 1 |
| Young, AB | 1 |
| Penney, JB | 1 |
| Mancini, WR | 1 |
6 other studies available for ro 5-4864 and Brain Neoplasms
| Article | Year |
|---|---|
Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzodiazepinones; Brain; Brain Neoplasms; Cell Death; D | 1997 |
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Computational Biol | 2014 |
Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.
Topics: Affinity Labels; Benzodiazepinones; Binding, Competitive; Brain Neoplasms; Cerebral Cortex; Glioma; | 1990 |
PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site.
Topics: Benzodiazepinones; Brain Neoplasms; Glioma; Humans; Receptors, GABA-A; Tomography, Emission-Computed | 1989 |
Peripheral benzodiazepine binding sites in human gliomas evaluated with positron emission tomography.
Topics: Benzodiazepinones; Brain Neoplasms; Carbon Radioisotopes; Glioma; Humans; Receptors, GABA-A; Tomogra | 1986 |
Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging.
Topics: Benzodiazepines; Benzodiazepinones; Brain Neoplasms; Cells, Cultured; Flunitrazepam; Glioma; Humans; | 1988 |