ro 5-4864 has been researched along with Brain Injuries in 6 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Brain injury after subarachnoid hemorrhage (SAH) is closely related to microglia/macrophages-induced neuroinflammation." | 1.56 | TSPO ligand Ro5-4864 modulates microglia/macrophages polarization after subarachnoid hemorrhage in mice. ( Chen, L; Du, F; Feng, Y; Guo, K; Jiang, Y; Peng, J; Xie, Y; Zhang, L; Zhang, X; Zhou, J, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, J | 1 |
| Zhang, X | 1 |
| Peng, J | 1 |
| Xie, Y | 1 |
| Du, F | 1 |
| Guo, K | 1 |
| Feng, Y | 1 |
| Zhang, L | 1 |
| Chen, L | 1 |
| Jiang, Y | 1 |
| Palzur, E | 1 |
| Sharon, A | 1 |
| Shehadeh, M | 1 |
| Soustiel, JF | 3 |
| Zaaroor, M | 2 |
| Vlodavsky, E | 2 |
| Veenman, L | 1 |
| Weizman, A | 1 |
| Gavish, M | 2 |
| Milman, F | 1 |
| Taupin, V | 2 |
| Toulmond, S | 2 |
| Benavides, J | 2 |
| Gogusev, J | 1 |
| Descamps-Latscha, B | 1 |
| Zavala, F | 2 |
| Serrano, A | 1 |
6 other studies available for ro 5-4864 and Brain Injuries
| Article | Year |
|---|---|
TSPO ligand Ro5-4864 modulates microglia/macrophages polarization after subarachnoid hemorrhage in mice.
Topics: Animals; Anti-Inflammatory Agents; Benzodiazepinones; Brain Injuries; Disease Models, Animal; Inflam | 2020 |
Investigation of the mechanisms of neuroprotection mediated by Ro5-4864 in brain injury.
Topics: Animals; Benzodiazepinones; Brain Injuries; Brain-Derived Neurotrophic Factor; Carrier Proteins; Cyc | 2016 |
Neuroprotective effect of Ro5-4864 following brain injury.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodiazepinones; Brain Injuries; Carrier Proteins; Casp | 2008 |
Improvement of cerebral metabolism mediated by Ro5-4864 is associated with relief of intracranial pressure and mitochondrial protective effect in experimental brain injury.
Topics: Animals; Benzodiazepinones; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Cerebrovascular Cir | 2011 |
Regulation of neural and peripheral cytokine production by benzodiazepines and endogenous anxiogenic peptides.
Topics: Animals; Benzodiazepinones; Brain Injuries; Carrier Proteins; Cerebral Cortex; Cytokines; Diazepam B | 1994 |
Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand.
Topics: Animals; Benzodiazepinones; Brain Injuries; Convulsants; Interleukin-1; Interleukin-6; Male; Rats; R | 1993 |