ro 5-4864 has been researched along with Benign Neoplasms, Brain in 6 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
| Excerpt | Relevance | Reference |
|---|---|---|
| " On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM." | 7.69 | Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. ( Basile, AS; Friedman, HS; Gallo, JM; Higgins, PE; Kupczyk-Subotkowska, L; Siahaan, TJ; Song, D, 1997) |
| " On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM." | 3.69 | Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. ( Basile, AS; Friedman, HS; Gallo, JM; Higgins, PE; Kupczyk-Subotkowska, L; Siahaan, TJ; Song, D, 1997) |
| "Binding of the isoquinoline PK 11195 and of the benzodiazepines Ro5-4864 and flunitrazepam was compared in glioma cells and tissues." | 3.67 | Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. ( Junck, L; Mancini, WR; Olson, JM; Penney, JB; Young, AB, 1988) |
| "Although gliomas have a high density of the peripheral-type benzodiazepine binding site, PET scans with a selective ligand for this site, [11C] Ro5-4864, failed to demonstrate higher radioactivity levels in human gliomas than in brain." | 1.28 | PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site. ( Ciliax, BJ; Jewett, DM; Junck, L; Kilbourn, MR; Koeppe, RA; McKeever, PE; Olson, JM; Starosta-Rubinstein, S; Watkins, GL; Wieland, DM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kupczyk-Subotkowska, L | 1 |
| Siahaan, TJ | 1 |
| Basile, AS | 1 |
| Friedman, HS | 1 |
| Higgins, PE | 1 |
| Song, D | 1 |
| Gallo, JM | 1 |
| Castellano, S | 1 |
| Taliani, S | 1 |
| Viviano, M | 1 |
| Milite, C | 1 |
| Da Pozzo, E | 1 |
| Costa, B | 1 |
| Barresi, E | 1 |
| Bruno, A | 1 |
| Cosconati, S | 1 |
| Marinelli, L | 1 |
| Greco, G | 1 |
| Novellino, E | 1 |
| Sbardella, G | 1 |
| Da Settimo, F | 1 |
| Martini, C | 1 |
| Broaddus, WC | 1 |
| Bennett, JP | 1 |
| Junck, L | 2 |
| Olson, JM | 2 |
| Ciliax, BJ | 1 |
| Koeppe, RA | 1 |
| Watkins, GL | 1 |
| Jewett, DM | 1 |
| McKeever, PE | 1 |
| Wieland, DM | 1 |
| Kilbourn, MR | 1 |
| Starosta-Rubinstein, S | 1 |
| Bergström, M | 1 |
| Mosskin, M | 1 |
| Ericson, K | 1 |
| Ehrin, E | 1 |
| Thorell, JO | 1 |
| von Holst, H | 1 |
| Norén, G | 1 |
| Persson, A | 1 |
| Halldin, C | 1 |
| Stone-Elander, S | 1 |
| Young, AB | 1 |
| Penney, JB | 1 |
| Mancini, WR | 1 |
6 other studies available for ro 5-4864 and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzodiazepinones; Brain; Brain Neoplasms; Cell Death; D | 1997 |
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Computational Biol | 2014 |
Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.
Topics: Affinity Labels; Benzodiazepinones; Binding, Competitive; Brain Neoplasms; Cerebral Cortex; Glioma; | 1990 |
PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site.
Topics: Benzodiazepinones; Brain Neoplasms; Glioma; Humans; Receptors, GABA-A; Tomography, Emission-Computed | 1989 |
Peripheral benzodiazepine binding sites in human gliomas evaluated with positron emission tomography.
Topics: Benzodiazepinones; Brain Neoplasms; Carbon Radioisotopes; Glioma; Humans; Receptors, GABA-A; Tomogra | 1986 |
Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging.
Topics: Benzodiazepines; Benzodiazepinones; Brain Neoplasms; Cells, Cultured; Flunitrazepam; Glioma; Humans; | 1988 |