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ro 5-4864 and Benign Neoplasms, Brain

ro 5-4864 has been researched along with Benign Neoplasms, Brain in 6 studies

4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor

Research Excerpts

ExcerptRelevanceReference
" On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM."7.69Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. ( Basile, AS; Friedman, HS; Gallo, JM; Higgins, PE; Kupczyk-Subotkowska, L; Siahaan, TJ; Song, D, 1997)
" On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM."3.69Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. ( Basile, AS; Friedman, HS; Gallo, JM; Higgins, PE; Kupczyk-Subotkowska, L; Siahaan, TJ; Song, D, 1997)
"Binding of the isoquinoline PK 11195 and of the benzodiazepines Ro5-4864 and flunitrazepam was compared in glioma cells and tissues."3.67Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging. ( Junck, L; Mancini, WR; Olson, JM; Penney, JB; Young, AB, 1988)
"Although gliomas have a high density of the peripheral-type benzodiazepine binding site, PET scans with a selective ligand for this site, [11C] Ro5-4864, failed to demonstrate higher radioactivity levels in human gliomas than in brain."1.28PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site. ( Ciliax, BJ; Jewett, DM; Junck, L; Kilbourn, MR; Koeppe, RA; McKeever, PE; Olson, JM; Starosta-Rubinstein, S; Watkins, GL; Wieland, DM, 1989)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kupczyk-Subotkowska, L1
Siahaan, TJ1
Basile, AS1
Friedman, HS1
Higgins, PE1
Song, D1
Gallo, JM1
Castellano, S1
Taliani, S1
Viviano, M1
Milite, C1
Da Pozzo, E1
Costa, B1
Barresi, E1
Bruno, A1
Cosconati, S1
Marinelli, L1
Greco, G1
Novellino, E1
Sbardella, G1
Da Settimo, F1
Martini, C1
Broaddus, WC1
Bennett, JP1
Junck, L2
Olson, JM2
Ciliax, BJ1
Koeppe, RA1
Watkins, GL1
Jewett, DM1
McKeever, PE1
Wieland, DM1
Kilbourn, MR1
Starosta-Rubinstein, S1
Bergström, M1
Mosskin, M1
Ericson, K1
Ehrin, E1
Thorell, JO1
von Holst, H1
Norén, G1
Persson, A1
Halldin, C1
Stone-Elander, S1
Young, AB1
Penney, JB1
Mancini, WR1

Other Studies

6 other studies available for ro 5-4864 and Benign Neoplasms, Brain

ArticleYear
Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate.
    Journal of medicinal chemistry, 1997, May-23, Volume: 40, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Benzodiazepinones; Brain; Brain Neoplasms; Cell Death; D

1997
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
    Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Computational Biol

2014
Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.
    Brain research, 1990, Jun-04, Volume: 518, Issue:1-2

    Topics: Affinity Labels; Benzodiazepinones; Binding, Competitive; Brain Neoplasms; Cerebral Cortex; Glioma;

1990
PET imaging of human gliomas with ligands for the peripheral benzodiazepine binding site.
    Annals of neurology, 1989, Volume: 26, Issue:6

    Topics: Benzodiazepinones; Brain Neoplasms; Glioma; Humans; Receptors, GABA-A; Tomography, Emission-Computed

1989
Peripheral benzodiazepine binding sites in human gliomas evaluated with positron emission tomography.
    Acta radiologica. Supplementum, 1986, Volume: 369

    Topics: Benzodiazepinones; Brain Neoplasms; Carbon Radioisotopes; Glioma; Humans; Receptors, GABA-A; Tomogra

1986
Isoquinoline and peripheral-type benzodiazepine binding in gliomas: implications for diagnostic imaging.
    Cancer research, 1988, Oct-15, Volume: 48, Issue:20

    Topics: Benzodiazepines; Benzodiazepinones; Brain Neoplasms; Cells, Cultured; Flunitrazepam; Glioma; Humans;

1988