ro 5-4864 has been researched along with Alzheimer Disease in 5 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "[3H]Flunitrazepam binding was decreased in these brain samples, possibly indicative of neuronal cell loss." | 1.27 | [3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type. ( Crow, TJ; Mashal, RD; Owen, F; Poulter, M; Waddington, JL, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, T | 1 |
| Son, WS | 1 |
| Morshed, MN | 1 |
| Londhe, AM | 1 |
| Jung, SY | 1 |
| Park, JH | 1 |
| Park, WK | 1 |
| Lim, SM | 1 |
| Park, KD | 1 |
| Cho, SJ | 1 |
| Jeong, KS | 1 |
| Lee, J | 1 |
| Pae, AN | 1 |
| Barron, AM | 1 |
| Garcia-Segura, LM | 1 |
| Caruso, D | 1 |
| Jayaraman, A | 1 |
| Lee, JW | 1 |
| Melcangi, RC | 1 |
| Pike, CJ | 1 |
| Owen, F | 1 |
| Poulter, M | 1 |
| Waddington, JL | 1 |
| Mashal, RD | 1 |
| Crow, TJ | 1 |
| Bongioanni, P | 1 |
| Castagna, M | 1 |
| Mondino, C | 1 |
| Boccardi, B | 1 |
| Borgna, M | 1 |
| McGeer, EG | 1 |
| Singh, EA | 1 |
| McGeer, PL | 1 |
5 other studies available for ro 5-4864 and Alzheimer Disease
| Article | Year |
|---|---|
Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Dogs; Dose-Response Relat | 2017 |
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzodiazepinones | 2013 |
[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.
Topics: Aged; Alzheimer Disease; Animals; Benzodiazepinones; Binding Sites; Corpus Striatum; Female; Flunitr | 1983 |
Platelet and lymphocyte benzodiazepine binding in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Benzodiazepines; Benzodiazepinones; Blood Platelets; Female; Humans; Lympho | 1997 |
Peripheral-type benzodiazepine binding in Alzheimer disease.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzodiazepinones; Cerebr | 1988 |