ro 5-4864 has been researched along with Alzheimer Disease in 5 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Excerpt | Relevance | Reference |
---|---|---|
"[3H]Flunitrazepam binding was decreased in these brain samples, possibly indicative of neuronal cell loss." | 1.27 | [3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type. ( Crow, TJ; Mashal, RD; Owen, F; Poulter, M; Waddington, JL, 1983) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (40.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (40.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kim, T | 1 |
Son, WS | 1 |
Morshed, MN | 1 |
Londhe, AM | 1 |
Jung, SY | 1 |
Park, JH | 1 |
Park, WK | 1 |
Lim, SM | 1 |
Park, KD | 1 |
Cho, SJ | 1 |
Jeong, KS | 1 |
Lee, J | 1 |
Pae, AN | 1 |
Barron, AM | 1 |
Garcia-Segura, LM | 1 |
Caruso, D | 1 |
Jayaraman, A | 1 |
Lee, JW | 1 |
Melcangi, RC | 1 |
Pike, CJ | 1 |
Owen, F | 1 |
Poulter, M | 1 |
Waddington, JL | 1 |
Mashal, RD | 1 |
Crow, TJ | 1 |
Bongioanni, P | 1 |
Castagna, M | 1 |
Mondino, C | 1 |
Boccardi, B | 1 |
Borgna, M | 1 |
McGeer, EG | 1 |
Singh, EA | 1 |
McGeer, PL | 1 |
5 other studies available for ro 5-4864 and Alzheimer Disease
Article | Year |
---|---|
Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Dogs; Dose-Response Relat | 2017 |
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzodiazepinones | 2013 |
[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.
Topics: Aged; Alzheimer Disease; Animals; Benzodiazepinones; Binding Sites; Corpus Striatum; Female; Flunitr | 1983 |
Platelet and lymphocyte benzodiazepine binding in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Benzodiazepines; Benzodiazepinones; Blood Platelets; Female; Humans; Lympho | 1997 |
Peripheral-type benzodiazepine binding in Alzheimer disease.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzodiazepinones; Cerebr | 1988 |