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ro 5-4864 and Alzheimer Disease

ro 5-4864 has been researched along with Alzheimer Disease in 5 studies

4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research Excerpts

ExcerptRelevanceReference
"[3H]Flunitrazepam binding was decreased in these brain samples, possibly indicative of neuronal cell loss."1.27[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type. ( Crow, TJ; Mashal, RD; Owen, F; Poulter, M; Waddington, JL, 1983)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, T1
Son, WS1
Morshed, MN1
Londhe, AM1
Jung, SY1
Park, JH1
Park, WK1
Lim, SM1
Park, KD1
Cho, SJ1
Jeong, KS1
Lee, J1
Pae, AN1
Barron, AM1
Garcia-Segura, LM1
Caruso, D1
Jayaraman, A1
Lee, JW1
Melcangi, RC1
Pike, CJ1
Owen, F1
Poulter, M1
Waddington, JL1
Mashal, RD1
Crow, TJ1
Bongioanni, P1
Castagna, M1
Mondino, C1
Boccardi, B1
Borgna, M1
McGeer, EG1
Singh, EA1
McGeer, PL1

Other Studies

5 other studies available for ro 5-4864 and Alzheimer Disease

ArticleYear
Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.
    European journal of medicinal chemistry, 2017, Dec-01, Volume: 141

    Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Dogs; Dose-Response Relat

2017
Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, May-15, Volume: 33, Issue:20

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzodiazepinones

2013
[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.
    Brain research, 1983, Nov-14, Volume: 278, Issue:1-2

    Topics: Aged; Alzheimer Disease; Animals; Benzodiazepinones; Binding Sites; Corpus Striatum; Female; Flunitr

1983
Platelet and lymphocyte benzodiazepine binding in patients with Alzheimer's disease.
    Experimental neurology, 1997, Volume: 146, Issue:2

    Topics: Aged; Alzheimer Disease; Benzodiazepines; Benzodiazepinones; Blood Platelets; Female; Humans; Lympho

1997
Peripheral-type benzodiazepine binding in Alzheimer disease.
    Alzheimer disease and associated disorders, 1988, Volume: 2, Issue:4

    Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzodiazepinones; Cerebr

1988