ro 48-8071 has been researched along with ER-Negative PR-Negative HER2-Negative Breast Cancer in 1 studies
Ro 48-8071: a cholesterol synthesis inhibitor; structure in first source
Ro 48-8071 : An aromatic ketone that is 2-fluoro-4'-bromobenzophenone in which the hydrogen at position 4 (meta to the fluoro group) is replaced by a 6-[methyl(prop-2-en-1-yl)amino]hexyl}oxy group. An inhibitor of lanosterol synthase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of human BT-474 breast cancer cells with RO reduced levels of estrogen-induced PR protein, confirming that RO blocks ERĪ± activity in tumor cells." | 1.40 | Cholesterol synthesis inhibitor RO 48-8071 suppresses transcriptional activity of human estrogen and androgen receptor. ( Hyder, SM; Liang, Y; Mafuvadze, B, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mafuvadze, B | 1 |
| Liang, Y | 1 |
| Hyder, SM | 1 |
1 other study available for ro 48-8071 and ER-Negative PR-Negative HER2-Negative Breast Cancer
| Article | Year |
|---|---|
Cholesterol synthesis inhibitor RO 48-8071 suppresses transcriptional activity of human estrogen and androgen receptor.
Topics: Atorvastatin; Benzophenones; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Estrogen R | 2014 |