ro-46-8443 and Hypertension

ro-46-8443 has been researched along with Hypertension* in 1 studies

Other Studies

1 other study(ies) available for ro-46-8443 and Hypertension

Article	Year
The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443. FEBS letters, 1996, Mar-25, Volume: 383, Issue:1-2 We used Ro 46-8443, non-peptidic antagonist selective of endothelin ETB receptors, to study the role of ETB receptors in rat hypertension models. In normotensive rats, Ro 46-8443 decreased blood pressure, but in SHR and DOCA rats, it induced a pressor effect, due to blockade of ETB-mediated release of nitric oxide since L-NAME prevented it. In rats rendered hypertensive by chronic L-NAME, Ro 46-8443 did not induce a pressor but depressor effect. Thus, in DOCA rats and SHR, Ro 46-8443 reveals a predominant influence of endothelial 'vasorelaxant' ETB receptors, while in normotensive rats the prevailing role of ETB receptors seems to be in mediating a vasoconstrictor tone. Topics: Animals; Arginine; Blood Pressure; Endothelin Receptor Antagonists; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides, Cyclic; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Viper Venoms	1996

Article

Year

The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443.

FEBS letters, 1996, Mar-25, Volume: 383, Issue:1-2

We used Ro 46-8443, non-peptidic antagonist selective of endothelin ETB receptors, to study the role of ETB receptors in rat hypertension models. In normotensive rats, Ro 46-8443 decreased blood pressure, but in SHR and DOCA rats, it induced a pressor effect, due to blockade of ETB-mediated release of nitric oxide since L-NAME prevented it. In rats rendered hypertensive by chronic L-NAME, Ro 46-8443 did not induce a pressor but depressor effect. Thus, in DOCA rats and SHR, Ro 46-8443 reveals a predominant influence of endothelial 'vasorelaxant' ETB receptors, while in normotensive rats the prevailing role of ETB receptors seems to be in mediating a vasoconstrictor tone.

Topics: Animals; Arginine; Blood Pressure; Endothelin Receptor Antagonists; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides, Cyclic; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Viper Venoms

1996