ro-41-5253 and Cleft-Palate

ro-41-5253 has been researched along with Cleft-Palate* in 1 studies

Other Studies

1 other study(ies) available for ro-41-5253 and Cleft-Palate

Article	Year
A retinoic acid receptor alpha antagonist counteracts retinoid teratogenicity in vitro and reduced incidence and/or severity of malformations in vivo. Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3 The role of retinoic acid receptors (RAR) in retinoid-induced teratogenesis is mainly unknown. The aim of the present studies was to demonstrate the effect of a RAR alpha antagonist on retinoid-induced teratogenic effects in vitro and in vivo. In micromass cultures of rat limb bud cells a RAR alpha antagonist was able to counteract differentiation inhibiting effects of a RAR alpha agonist. In mouse studies, the selective RAR alpha antagonist reduced frequency and/or severity of major malformations. Our observations indicate the potentiality of selective RAR agonists and antagonists in dissecting the function of nuclear receptors and in particular cases of retinoid teratogenesis, to assign to the different receptors a primary role in determining one or another of the multiple malformations. Topics: Abnormalities, Drug-Induced; Animals; Benzoates; Cell Differentiation; Cells, Cultured; Chromans; Cleft Palate; Ear, External; Extremities; Female; Mice; Pregnancy; Rats; Receptors, Retinoic Acid; Retinoids; Tetrahydronaphthalenes	1994

Article

Year

A retinoic acid receptor alpha antagonist counteracts retinoid teratogenicity in vitro and reduced incidence and/or severity of malformations in vivo.

Toxicology letters, 1994, Feb-15, Volume: 70, Issue:3

The role of retinoic acid receptors (RAR) in retinoid-induced teratogenesis is mainly unknown. The aim of the present studies was to demonstrate the effect of a RAR alpha antagonist on retinoid-induced teratogenic effects in vitro and in vivo. In micromass cultures of rat limb bud cells a RAR alpha antagonist was able to counteract differentiation inhibiting effects of a RAR alpha agonist. In mouse studies, the selective RAR alpha antagonist reduced frequency and/or severity of major malformations. Our observations indicate the potentiality of selective RAR agonists and antagonists in dissecting the function of nuclear receptors and in particular cases of retinoid teratogenesis, to assign to the different receptors a primary role in determining one or another of the multiple malformations.

Topics: Abnormalities, Drug-Induced; Animals; Benzoates; Cell Differentiation; Cells, Cultured; Chromans; Cleft Palate; Ear, External; Extremities; Female; Mice; Pregnancy; Rats; Receptors, Retinoic Acid; Retinoids; Tetrahydronaphthalenes

1994