ro-41-5253 has been researched along with Carcinoma--Embryonal* in 1 studies
1 other study(ies) available for ro-41-5253 and Carcinoma--Embryonal
| Article | Year |
|---|---|
A putative G-protein-coupled receptor, H218, is down-regulated during the retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
We have previously cloned a novel guanine nucleotide-binding protein (G-protein)-coupled receptor, H218, that has sequence similarity to a lysophosphatidic acid receptor, edg2. We present here Northern analysis indicating that the H218 mRNA is expressed in undifferentiated F9 embryonal carcinoma cells. The H218 message is down-regulated and its stability is decreased during retinoic acid- and dibutyryl cAMP-induced differentiation. Treatment by various receptor-selective retinoids indicated that retinoic acid receptor beta or gamma signaling, but not retinoid X receptor activation, is required for the down-regulation of H218 mRNA. Activation of the H218 receptor may contribute to the phenotype of undifferentiated F9 embryonal carcinoma cells. Topics: Animals; Benzoates; Bucladesine; Carcinoma, Embryonal; Cell Differentiation; Chromans; Down-Regulation; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Mice; Naphthalenes; Neoplasm Proteins; Phenotype; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Receptors, Retinoic Acid; Retinoids; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetrahydronaphthalenes; Tretinoin; Tumor Cells, Cultured | 1998 |