ro-4-6790 and Memory-Disorders

ro-4-6790 has been researched along with Memory-Disorders* in 1 studies

Other Studies

1 other study(ies) available for ro-4-6790 and Memory-Disorders

Article	Year
5-HT(6) receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides. European journal of medicinal chemistry, 2001, Volume: 36, Issue:2 RO-04-6790 (6a) has been identified in a random screen for 5-HT(6) receptor antagonists. In a medicinal chemistry optimisation program a series of analogs comprising N-heteroaryl- and N-arylbenzenesulfonamides have been synthesised and investigated for their binding affinity. Compounds with a logD profile indicative of brain penetration have been subjected to in vivo testing for reversal of a scopolamine-induced retention deficit in a passive avoidance paradigm. Topics: Animals; Binding, Competitive; Biological Availability; Humans; Memory Disorders; Protein Binding; Pyrimidines; Rats; Receptors, Serotonin; Scopolamine; Serotonin Antagonists; Sulfanilamide; Sulfanilamides	2001

Article

Year

5-HT(6) receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides.

European journal of medicinal chemistry, 2001, Volume: 36, Issue:2

RO-04-6790 (6a) has been identified in a random screen for 5-HT(6) receptor antagonists. In a medicinal chemistry optimisation program a series of analogs comprising N-heteroaryl- and N-arylbenzenesulfonamides have been synthesised and investigated for their binding affinity. Compounds with a logD profile indicative of brain penetration have been subjected to in vivo testing for reversal of a scopolamine-induced retention deficit in a passive avoidance paradigm.

Topics: Animals; Binding, Competitive; Biological Availability; Humans; Memory Disorders; Protein Binding; Pyrimidines; Rats; Receptors, Serotonin; Scopolamine; Serotonin Antagonists; Sulfanilamide; Sulfanilamides

2001