ro 31-8220 has been researched along with Neuroblastoma in 9 studies
Ro 31-8220: a protein kinase C inhibitor
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A human neuroblastoma cell line, IMR-32, was used as an in vitro model system to study the effects of arsenic trioxide (As(2)O(3)) on aggressive human neuroblastoma." | 7.74 | Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells. ( Cheung, WM; Chu, PW; Kwong, YL, 2007) |
| "Lithium, carbamazepine and sodium valproate are mood stabilizers used in the treatment of bipolar disorder, and although their mechanisms of action remain unknown, signal transduction systems and the associated modulation of gene expression may constitute significant actions." | 7.70 | Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells. ( Jope, RS; Pacheco, MA, 1999) |
| "A human neuroblastoma cell line, IMR-32, was used as an in vitro model system to study the effects of arsenic trioxide (As(2)O(3)) on aggressive human neuroblastoma." | 3.74 | Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells. ( Cheung, WM; Chu, PW; Kwong, YL, 2007) |
| "Lithium, carbamazepine and sodium valproate are mood stabilizers used in the treatment of bipolar disorder, and although their mechanisms of action remain unknown, signal transduction systems and the associated modulation of gene expression may constitute significant actions." | 3.70 | Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells. ( Jope, RS; Pacheco, MA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, CY | 1 |
| Ma, KH | 1 |
| Wang, JK | 1 |
| Tung, YL | 1 |
| Chueh, SH | 1 |
| Cheung, WM | 1 |
| Chu, PW | 1 |
| Kwong, YL | 1 |
| Purkiss, JR | 1 |
| Smart, D | 1 |
| Lambert, DG | 2 |
| Willets, JM | 1 |
| Lunec, J | 1 |
| Griffiths, HR | 1 |
| Rösner, H | 1 |
| Fischer, H | 1 |
| Pacheco, MA | 1 |
| Jope, RS | 1 |
| Webster, NJ | 1 |
| Vaughan, PF | 1 |
| Peers, C | 1 |
| Wilkes, LC | 1 |
| Boarder, MR | 1 |
9 other studies available for ro 31-8220 and Neuroblastoma
| Article | Year |
|---|---|
Inhibition of protein kinase C promotes differentiation of neuroblastoma × glioma NG108-15 hybrid cells.
Topics: Animals; Carbazoles; Cell Count; Cell Differentiation; Cell Line, Tumor; Cell Shape; Enzyme Inhibito | 2011 |
Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Cell Differentiation; Cell Line, Tumor; | 2007 |
Activation of phospholipase D in SH-SY5Y neuroblastoma cells: dependence on Ca2+ and protein kinase C.
Topics: Bradykinin; Calcium; Calcium-Transporting ATPases; Enzyme Activation; Enzyme Inhibitors; Humans; Ind | 1995 |
Desensitization of the mu-opioid activation of phospholipase C in SH-SY5Y cells: the role of protein kinases C and A and Ca(2+)-activated K+ currents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells.
Topics: Adenylyl Cyclases; Adrenergic Uptake Inhibitors; Catecholamines; Cell Death; Clorgyline; Dose-Respon | 1995 |
In growth cones of rat cerebral neurons and human neuroblastoma cells, activation of protein kinase C causes a shift from filopodial to lamellipodial actin dynamics.
Topics: Actins; Animals; Brain; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Neuroblastoma; Neuron | 1996 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calc | 1999 |
Hypoxic enhancement of evoked noradrenaline release from the human neuroblastoma SH-SY5Y.
Topics: Calcium; Cell Hypoxia; Chronic Disease; Electric Stimulation; Enzyme Inhibitors; Exocytosis; Humans; | 2001 |
Evidence for a novel mechanism of activation of phospholipase D by endothelin-1 in neuroblastoma cells.
Topics: Animals; Calcimycin; Endothelins; Enzyme Activation; Indoles; Kinetics; Neuroblastoma; Phospholipase | 1992 |